Evidence map›Paper›PMID 34502151›Full record

ArticleInternational journal of molecular sciences2021

The Amino Acid-mTORC1 Pathway Mediates APEC TW-XM-Induced Inflammation in bEnd.3 Cells.

Dong Zhang, Shu Xu, Yiting Wang, Peng Bin, Guoqiang Zhu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. The Role ofVeterinary sciences · 2025
    Article
  2. Melatonin Is Neuroprotective inInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Dong ZhangCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Shu XuCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Yiting WangCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Peng BinCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Guoqiang ZhuCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Yangzhou University · CN

Funding

Ministry of Science and Technology of the People's Republic of China 2016YFD0500905Ministry of Science and Technology of the People's Republic of China 2017YFD0500203National Natural Science Foundation of China 31922079The National Natural Science Foundation of China 31790411The National Natural Science Foundation of China 31872365
6 · The paper itself

Abstract

The blood-brain barrier (BBB) is key to establishing and maintaining homeostasis in the central nervous system (CNS); meningitis bacterial infection can disrupt the integrity of BBB by inducing an inflammatory response. The changes in the cerebral uptake of amino acids may contribute to inflammatory response during infection and were accompanied by high expression of amino acid transporters leading to increased amino acid uptake. However, it is unclear whether amino acid uptake is changed and how to affect inflammatory responses in mouse brain microvascular endothelial (bEnd.3) cells in response to Avian Pathogenic

Indexed as

Escherichia coliAmino AcidsAmino Acid Transport SystemsAnimalsBird DiseasesBlood-Brain BarrierCell LineDisease Models, AnimalEndothelial CellsGlutamic AcidInflammationMechanistic Target of Rapamycin Complex 1MiceSerineAmino AcidsAmino Acid Transport SystemsGlutamic AcidMechanistic Target of Rapamycin Complex 1Serineamino acidsamino acid transporterAPEC XMblood–brain barrierinflammationmTORC1 pathway

Identifiers

PMID34502151
PMCPMC8431488
OpenAlexW3193980142

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.