Evidence map›Paper›PMID 34502130›Full record

ReviewInternational journal of molecular sciences2021

The Role of the PFNA Operon of Bifidobacteria in the Recognition of Host's Immune Signals: Prospects for the Use of the FN3 Protein in the Treatment of COVID-19.

Venera Z Nezametdinova, Roman A Yunes, Marina S Dukhinova, Maria G Alekseeva, Valery N Danilenko

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Differential Binding of ΔFN3 Proteins ofInternational journal of molecular sciences · 2025
    Article
  2. Review
  3. Article
  4. Identification of a prototype human gutFrontiers in microbiology · 2023
    Article
  5. Study of the binding of ΔFN3.1 fragments of theMicrobiome research reports · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Venera Z NezametdinovaLaboratory of Bacterial Genetics, The Vavilov Institute of General Genetics, 117971 Moscow, Russia.
Roman A YunesLaboratory of Bacterial Genetics, The Vavilov Institute of General Genetics, 117971 Moscow, Russia.ORCID 0000-0001-6283-6258
Marina S DukhinovaInternational Institute 'Solution Chemistry of Advanced Materials and Technologies', ITMO University, 197101 Saint-Petersburg, Russia.
Maria G AlekseevaLaboratory of Bacterial Genetics, The Vavilov Institute of General Genetics, 117971 Moscow, Russia.
Valery N DanilenkoLaboratory of Bacterial Genetics, The Vavilov Institute of General Genetics, 117971 Moscow, Russia.
Vavilov Institute of General Genetics · RUITMO University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bifidobacteria are some of the major agents that shaped the immune system of many members of the animal kingdom during their evolution. Over recent years, the question of concrete mechanisms underlying the immunomodulatory properties of bifidobacteria has been addressed in both animal and human studies. A possible candidate for this role has been discovered recently. The PFNA cluster, consisting of five core genes,

Indexed as

Bacterial ProteinsBifidobacteriumCOVID-19Cytokine Release SyndromeCytokinesHumansImmune SystemOperonProtein Serine-Threonine KinasesSARS-CoV-2Bacterial ProteinsCytokinesProtein Serine-Threonine Kinasesbifidobacteriaevolutionhost-microbe interactionimmune systemPFNA operon

Identifiers

PMID34502130
PMCPMC8430577
OpenAlexW3193505846

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.