Evidence map›Paper›PMID 34502123›Full record

ReviewInternational journal of molecular sciences2021

The Use of Infrapatellar Fat Pad-Derived Mesenchymal Stem Cells in Articular Cartilage Regeneration: A Review.

Parviz Vahedi, Rana Moghaddamshahabi, Thomas J Webster, Ayse Ceren Calikoglu Koyuncu, Elham Ahmadian, Wasim S Khan, Ali Jimale Mohamed, Aziz Eftekhari

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
17.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 7 countries.

Parviz VahediDepartment of Anatomical Sciences, Maragheh University of Medical Sciences, Maragheh 78151-55158, Iran.
Rana MoghaddamshahabiFaculty of Pharmacy, Eastern Mediterranean University, Famagusta 99628, North Cyprus, Turkey.
Thomas J WebsterDepartment of Chemical Engineering, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA.ORCID 0000-0002-2028-5969
Ayse Ceren Calikoglu KoyuncuMaterials and Metallurgical Engineering Department, Faculty of Technology, Marmara University, Istanbul 34722, Turkey.ORCID 0000-0002-0318-6037
Elham AhmadianKidney Research Center, Tabriz University of Medical Sciences, Tabriz 51666-15731, Iran.ORCID 0000-0002-7230-0489
Wasim S KhanDivision of Trauma & Orthopaedic Surgery, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0003-3106-5424
Ali Jimale MohamedDepartment of Pharmacology, Faculty of Medicine, Somali National University, Mogadishu 801, Somalia.
Aziz EftekhariDepartment of Toxicology and Pharmacology, Maragheh University of Medical Sciences, Maragheh 78151-55158, Iran.
University of Maragheh · IREastern Mediterranean University · CYMarmara University · TRNortheastern University · USSomali National University · SOTabriz University of Medical Sciences · IRUniversity of Cambridge · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cartilage is frequently damaged with a limited capacity for repair. Current treatment strategies are insufficient as they form fibrocartilage as opposed to hyaline cartilage, and do not prevent the progression of degenerative changes. There is increasing interest in the use of autologous mesenchymal stem cells (MSC) for tissue regeneration. MSCs that are used to treat articular cartilage defects must not only present a robust cartilaginous production capacity, but they also must not cause morbidity at the harvest site. In addition, they should be easy to isolate from the tissue and expand in culture without terminal differentiation. The source of MSCs is one of the most important factors that may affect treatment. The infrapatellar fat pad (IPFP) acts as an important reservoir for MSC and is located in the anterior compartment of the knee joint in the extra-synovial area. The IPFP is a rich source of MSCs, and in this review, we discuss studies that demonstrate that these cells have shown many advantages over other tissues in terms of ease of isolation, expansion, and chondrogenic differentiation. Future studies in articular cartilage repair strategies and suitable extraction as well as cell culture methods will extend the therapeutical application of IPFP-derived MSCs into additional orthopedic fields, such as osteoarthritis. This review provides the latest research concerning the use of IPFP-derived MSCs in the treatment of articular cartilage damage, providing critical information for the field to grow.

Indexed as

Bone RegenerationAdipose TissueAnimalsCartilage, ArticularCell- and Tissue-Based TherapyCell Culture TechniquesHumansMesenchymal Stem CellsOsteogenesisWound Healingadipose tissuearticular cartilageinfrapatellar fat padmesenchymal stem cellsosteoarthritis

Identifiers

PMID34502123
PMCPMC8431575
OpenAlexW3193795627

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.