Altered Secretome of Diabetic Monocytes Could Negatively Influence Fracture Healing-An In Vitro Study.

Caren Linnemann, Lorena Savini, Mika F Rollmann, Tina Histing, Andreas K Nussler, Sabrina Ehnert

Open access · goldAbstract read

In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed, 1 pooled it

0.5field-weighted citation impact, top 38% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

Bone marrow aspirate and bone marrow aspirate concentrate: Does the literature support use in long-bone nonunion and provide new insights into mechanism of action?European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024
Pooled it
Effects of circulating inflammatory proteins on spinal degenerative diseases: Evidence from genetic correlations and Mendelian randomization study.JOR spine · 2024
Article
Insulin Can Delay Neutrophil Extracellular Trap Formation In Vitro-Implication for Diabetic Wound Care?Biology · 2023
Article
Febrile-Range Hyperthermia Can Prevent Toxic Effects of Neutrophil Extracellular Traps on Mesenchymal Stem Cells.International journal of molecular sciences · 2022
Article
Modulation of Macrophage Activity by Pulsed Electromagnetic Fields in the Context of Fracture Healing.Bioengineering (Basel, Switzerland) · 2021
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Caren LinnemannSiegfried Weller Research Institute, Department of Trauma and Reconstructive Surgery, BG Trauma Center Tübingen, University of Tübingen, Schnarrenbergstr. 95, D-72076 Tübingen, Germany.ORCID 0000-0002-4934-2728

Lorena SaviniSiegfried Weller Research Institute, Department of Trauma and Reconstructive Surgery, BG Trauma Center Tübingen, University of Tübingen, Schnarrenbergstr. 95, D-72076 Tübingen, Germany.ORCID 0000-0002-2978-051X

Mika F RollmannSiegfried Weller Research Institute, Department of Trauma and Reconstructive Surgery, BG Trauma Center Tübingen, University of Tübingen, Schnarrenbergstr. 95, D-72076 Tübingen, Germany.

Tina HistingSiegfried Weller Research Institute, Department of Trauma and Reconstructive Surgery, BG Trauma Center Tübingen, University of Tübingen, Schnarrenbergstr. 95, D-72076 Tübingen, Germany.

Andreas K NusslerSiegfried Weller Research Institute, Department of Trauma and Reconstructive Surgery, BG Trauma Center Tübingen, University of Tübingen, Schnarrenbergstr. 95, D-72076 Tübingen, Germany.ORCID 0000-0002-6666-6791

Sabrina EhnertSiegfried Weller Research Institute, Department of Trauma and Reconstructive Surgery, BG Trauma Center Tübingen, University of Tübingen, Schnarrenbergstr. 95, D-72076 Tübingen, Germany.ORCID 0000-0003-4347-1702

University of Tübingen · DE

Funding

Deutsche Forschungsgemeinschaft EH 471/2Studienstiftung des Deutschen Volkes Stipendium CL

6 · The paper itself

Abstract

Diabetes mellitus is a main risk factor for delayed fracture healing and fracture non-unions. Successful fracture healing requires stimuli from different immune cells, known to be affected in diabetics. Especially, application of mononuclear cells has been proposed to promote wound and fracture healing. Thus, aim was to investigate the effect of pre-/diabetic conditions on mononuclear cell functions essential to promote osteoprogenitor cell function. We here show that pre-/diabetic conditions suppress the expression of chemokines, e.g.,

Indexed as

Fracture HealingAnimalsBiomarkersCell MovementCells, CulturedChemokine CCL2Chemokine CCL8ChemokinesChemotaxis, LeukocyteCulture Media, ConditionedDiabetes MellitusHumansHyperglycemiaLeukocytes, MononuclearMAP Kinase Signaling SystemMonocytesBiomarkersCCL2 protein, humanCCL8 protein, humanChemokine CCL2Chemokine CCL8ChemokinesCulture Media, Conditionedchemokinesdiabetes mellitusERK1/2fracturemigrationmononuclear cellsosteoprogenitor cells

Identifiers

PMID34502120

DOI10.3390/ijms22179212

PMCPMC8430926

OpenAlexW3195838276

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.