Evidence map›Paper›PMID 34502098›Full record

ArticleInternational journal of molecular sciences2021

Compromised Biomechanical Properties, Cell-Cell Adhesion and Nanotubes Communication in Cardiac Fibroblasts Carrying the Lamin A/C D192G Mutation.

Veronique Lachaize, Brisa Peña, Catalin Ciubotaru, Dan Cojoc, Suet Nee Chen, Matthew R G Taylor, Luisa Mestroni, Orfeo Sbaizero

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. CCR2Frontiers in pharmacology · 2026
    Article
  3. Stress transmission towards the nucleus of the cell.Frontiers in cell and developmental biology · 2026
    Review
  4. Review
  5. Review
  6. Atomic Force Microscopy (AFM) Applications in Arrhythmogenic Cardiomyopathy.International journal of molecular sciences · 2022
    Review
  7. Transcriptional Regulation of Cardiac Development and Disease.International journal of molecular sciences · 2022
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Veronique LachaizeDepartment of Engineering and Architecture, University of Trieste, Via Valerio 10, 34127 Trieste, Italy.
Brisa PeñaCU-Cardiovascular Institute, University of Colorado Anschutz Medical Campus, 12700 E. 19th Ave., Aurora, CO 80045, USA.ORCID 0000-0003-4224-6626
Catalin CiubotaruInstitute of Materials, National Research Council of Italy (CNR_IOM), Area Science Park Basovizza, 34149 Trieste, Italy.
Dan CojocInstitute of Materials, National Research Council of Italy (CNR_IOM), Area Science Park Basovizza, 34149 Trieste, Italy.
Suet Nee ChenCU-Cardiovascular Institute, University of Colorado Anschutz Medical Campus, 12700 E. 19th Ave., Aurora, CO 80045, USA.
Matthew R G TaylorCU-Cardiovascular Institute, University of Colorado Anschutz Medical Campus, 12700 E. 19th Ave., Aurora, CO 80045, USA.ORCID 0000-0001-9043-0810
Luisa MestroniCU-Cardiovascular Institute, University of Colorado Anschutz Medical Campus, 12700 E. 19th Ave., Aurora, CO 80045, USA.ORCID 0000-0003-1116-2286
Orfeo SbaizeroDepartment of Engineering and Architecture, University of Trieste, Via Valerio 10, 34127 Trieste, Italy.ORCID 0000-0002-8933-5071
University of Colorado Anschutz Medical Campus · USAREA Science Park · ITUniversity of Trieste · IT

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
Genetics, Mechanisms and Clinical Phenotypes of Arrhythmogenic CardiomyopathyR01HL116906 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI MARCUS, FRANK I, MESTRONI, LUISA · 2013 to 2016
$9.2M
Whole genome DNA sequencing to identify novel genes in dilated cardiomyopathyR01HL109209 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI TAYLOR, MATTHEW R · 2012 to 2016
$2.1M
Cardiomyocyte phenotype and mechanotransduction in Filamin C gene variants causing arrhythmogenic cardiomyopathyR01HL147064 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MESTRONI, LUISA, TAYLOR, MATTHEW R · 2020 to 2023
$2.1M
Injectable Carbon Nanotube-Functionalized Hydrogel for miRNA DeliveryK25HL148386 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI PENA CASTELLANOS, BRISA MARISOL · 2020 to 2024
$891k
NCATS NIH HHS UL1TR001082NCATS NIH HHS UL1 TR002535NCATS NIH HHS UL1TR002535NHLBI NIH HHS K25 HL148386NIH HHS 1K23HI067915NIH HHS 2UM1HG006542NIH HHS R01HL109209NIH HHS R01HL116906NIH HHS R01HL147064NIH HHS R01HL 63020800NIH HHS R01HL69071
6 · The paper itself

Abstract

Clinical effects induced by arrhythmogenic cardiomyopathy (ACM) originate from a large spectrum of genetic variations, including the missense mutation of the lamin A/C gene (

Indexed as

Cell AdhesionActin CytoskeletonAnimalsCells, CulturedLamin Type AMicroscopy, Atomic ForceMutation, MissenseMyocytes, CardiacMyofibroblastsNanotubesOptical TweezersRatsRats, Sprague-DawleyLamin Type Aarrhythmogenic cardiomyopathy (ACM)atomic force microscopy (AFM)cell–cell adhesionlamin A/Cneonatal rat ventricular fibroblasts (NRVF)tunneling nanotubes (TNT)

Identifiers

PMID34502098
PMCPMC8431729
OpenAlexW3193956013

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.