Evidence map›Paper›PMID 34502082›Full record

ArticleInternational journal of molecular sciences2021

The Long Non-Coding RNA H19 Drives the Proliferation of Diffuse Intrinsic Pontine Glioma with H3K27 Mutation.

David Roig-Carles, Holly Jackson, Katie F Loveson, Alan Mackay, Rebecca L Mather, Ella Waters, Massimiliano Manzo, Ilaria Alborelli, Jon Golding, Chris Jones and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

David Roig-CarlesCancer Research Group, School of Life, Health and Chemical Sciences, The Open University, Milton Keynes MK7 6AA, UK.
Holly JacksonCancer Research Group, School of Life, Health and Chemical Sciences, The Open University, Milton Keynes MK7 6AA, UK.
Katie F LovesonSchool of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2UP, UK.ORCID 0000-0001-5569-4327
Alan MackayDivision of Molecular Pathology, The Institute of Cancer Research, London SW7 3RP, UK.
Rebecca L MatherCancer Research Group, School of Life, Health and Chemical Sciences, The Open University, Milton Keynes MK7 6AA, UK.
Ella WatersCancer Research Group, School of Life, Health and Chemical Sciences, The Open University, Milton Keynes MK7 6AA, UK.
Massimiliano ManzoInstitute of Pathology, University Hospital Basel, 4031 Basel, Switzerland.
Ilaria AlborelliInstitute of Pathology, University Hospital Basel, 4031 Basel, Switzerland.ORCID 0000-0001-7849-3958
Jon GoldingCancer Research Group, School of Life, Health and Chemical Sciences, The Open University, Milton Keynes MK7 6AA, UK.ORCID 0000-0002-7910-7382
Chris JonesDivision of Molecular Pathology, The Institute of Cancer Research, London SW7 3RP, UK.
Helen L FillmoreSchool of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2UP, UK.ORCID 0000-0003-4131-579X
Francesco CreaCancer Research Group, School of Life, Health and Chemical Sciences, The Open University, Milton Keynes MK7 6AA, UK.
The Open University · GBInstitute of Cancer Research · GBUniversity Hospital of Basel · CHUniversity of Portsmouth · GB

Funding

Abbie's Army Development of H19-targeting antisense oligonucleotides for DIPG therapy
6 · The paper itself

Abstract

Diffuse intrinsic pontine glioma (DIPG) is an incurable paediatric malignancy. Identifying the molecular drivers of DIPG progression is of the utmost importance. Long non-coding RNAs (lncRNAs) represent a large family of disease- and tissue-specific transcripts, whose functions have not yet been elucidated in DIPG. Herein, we studied the oncogenic role of the development-associated

Indexed as

Cell ProliferationBrain Stem NeoplasmsCells, CulturedGene Expression Regulation, NeoplasticGliomaHistonesHumansMicroRNAsMutationRNA, Long NoncodingH19 long non-coding RNAHistonesMicroRNAsmirnlet7 microRNA, humanRNA, Long Noncodingbrain cancerdiffuse midline gliomaDIPGepigeneticslncRNApaediatric glioma

Identifiers

PMID34502082
PMCPMC8431314
OpenAlexW3195919139

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.