Evidence map›Paper›PMID 34502071›Full record

ArticleInternational journal of molecular sciences2021

Allicin May Promote Reversal of T-Cell Dysfunction in Periodontitis via the

Shankargouda Patil, Mohammed E Sayed, Maryam H Mugri, Khalaf F Alsharif, Arif Salman, Shilpa Bhandi, Hosam Ali Baeshen, Thodur Madapusi Balaji, Pradeep Kumar Yadalam, Saranya Varadarajan and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Effect and mechanism of Sanqi () in treating periodontitis.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

Shankargouda PatilDepartment of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan 45412, Saudi Arabia.ORCID 0000-0001-7246-5497
Mohammed E SayedDepartment of Prosthetic Dental Sciences, College of Dentistry, Jazan University, Jazan 45412, Saudi Arabia.ORCID 0000-0001-8667-8987
Maryam H MugriDepartment of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan 45412, Saudi Arabia.
Khalaf F AlsharifDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID 0000-0002-8156-2069
Arif SalmanDepartment of Periodontics, School of Dentistry, West Virginia University, P.O. Box 9490, Morgantown, WV 26506, USA.
Shilpa BhandiDepartment of Restorative Dental Sciences, College of Dentistry, Jazan University, Jazan 45412, Saudi Arabia.
Hosam Ali BaeshenDepartment of Orthodontics, College of Dentistry, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Thodur Madapusi BalajiTagore Dental College and Hospital, Chennai 600127, India.
Pradeep Kumar YadalamDepartment of Periodontics, Adhi Parashakthi Dental College, Melvaruvathur 603319, India.
Saranya VaradarajanDepartment of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai 600130, India.ORCID 0000-0002-7051-1143
R Srimathi R RadhaSRM College of Pharmacy, Kancheepuram 603203, India.
Kamran Habib AwanCollege of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT 84095, USA.
Vikrant R PatilBiogenre Private Limited, Pune 412105, India.ORCID 0000-0003-0017-5807
A Thirumal RajDepartment of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai 600130, India.ORCID 0000-0002-1079-1024
Jazan University · SASri Venkateswara Medical College and Ruia Hospital · INKing Abdulaziz University · SARagas Dental College & Hospital · INRoseman University of Health Sciences · USTaif University · SAWest Virginia University · US

Funding

TAIF UNIVERSITY RESEARCHERS SUPPORTING PROGRAM TURSP-2020/153
6 · The paper itself

Abstract

We evaluated the role of allicin in periodontitis using an in silico and in vitro design. An in silico docking analysis was performed to assess the plausible interactions between allicin and

Indexed as

Antigens, CDB7-H1 AntigenBinding SitesCells, CulturedChemokine CCL2Chemokine CXCL6DisulfidesHepatitis A Virus Cellular Receptor 2HumansInterferon-gammaInterleukin-6Lymphocyte Activation Gene 3 ProteinPeriodontitisProtein BindingSulfinic AcidsT-LymphocytesallicinAntigens, CDB7-H1 AntigenCCL2 protein, humanCD274 protein, humanChemokine CCL2Chemokine CXCL6CXCL6 protein, humanDisulfidesHAVCR2 protein, humanHepatitis A Virus Cellular Receptor 2Interferon-gammaInterleukin-6Lag3 protein, humanLymphocyte Activation Gene 3 ProteinSulfinic AcidsTumor Necrosis Factor-alphaallicingingival crevicular fluidperiodontitisT lymphocytes

Identifiers

PMID34502071
PMCPMC8431528
OpenAlexW3196167269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.