Evidence map›Paper›PMID 34502070›Full record

ArticleInternational journal of molecular sciences2021

Immune Cells Invade the Collateral Circulation during Human Stroke: Prospective Replication and Extension.

Marc Strinitz, Mirko Pham, Alexander G März, Jörn Feick, Franziska Weidner, Marius L Vogt, Fabian Essig, Hermann Neugebauer, Guido Stoll, Michael K Schuhmann and 1 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06963489 (Cerebral Large Vessel Occlusion Stroke Multiomics Biosample Cohort), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06963489 recruitingnot on this mapstarted 2025, after this paper: background citation

Cerebral Large Vessel Occlusion Stroke Multiomics Biosample Cohort

TypeobservationalSponsorFirst Affiliated Hospital of Wannan Medical CollegeRan2025 to 2028Enrolled500ConditionsLarge Vessel Occlusion, Acute Ischemic StrokeArmsNot applicable- observational study
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Genetic determinants of insufficiency of the collateral circulation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Observational
  7. Review
  8. Cellular and Molecular Targets in Acute Ischemic Stroke.International journal of molecular sciences · 2022
    Article
  9. An intravascular perspective on hyper-acute neutrophil, T-cell and platelet responses: Similarities between human and experimental stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  10. Review
  11. Defining cerebral leukocyte populations in local ischemic blood samples from patients with hyperacute stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Marc StrinitzDepartment of Neuroradiology, University Hospital of Würzburg, 97080 Würzburg, Germany.
Mirko PhamDepartment of Neuroradiology, University Hospital of Würzburg, 97080 Würzburg, Germany.
Alexander G MärzDepartment of Neuroradiology, University Hospital of Würzburg, 97080 Würzburg, Germany.
Jörn FeickDepartment of Neuroradiology, University Hospital of Würzburg, 97080 Würzburg, Germany.
Franziska WeidnerDepartment of Neuroradiology, University Hospital of Würzburg, 97080 Würzburg, Germany.
Marius L VogtDepartment of Neuroradiology, University Hospital of Würzburg, 97080 Würzburg, Germany.
Fabian EssigDepartment of Neurology, University Hospital of Würzburg, 97080 Würzburg, Germany.
Hermann NeugebauerDepartment of Neurology, University Hospital of Würzburg, 97080 Würzburg, Germany.
Guido StollDepartment of Neurology, University Hospital of Würzburg, 97080 Würzburg, Germany.
Michael K SchuhmannDepartment of Neurology, University Hospital of Würzburg, 97080 Würzburg, Germany.
Alexander M KollikowskiDepartment of Neuroradiology, University Hospital of Würzburg, 97080 Würzburg, Germany.ORCID 0000-0002-0288-5928
Universitätsklinikum Würzburg · DE

Funding

Deutsche Forschungsgemeinschaft project number 374031971Deutsche Forschungsgemeinschaft project number 413657723
6 · The paper itself

Abstract

It remains unclear if principal components of the local cerebral stroke immune response can be reliably and reproducibly observed in patients with acute large-vessel-occlusion (LVO) stroke. We prospectively studied a large independent cohort of

Indexed as

Collateral CirculationAgedAged, 80 and overCerebral ArteriesFemaleHumansIschemic StrokeLeukocytesMaleMiddle AgedNeutrophilscerebral ischemiacollateral circulationischemic strokelarge vessel occlusionleukocytesmechanical thrombectomyneutrophils

Identifiers

PMID34502070
PMCPMC8430889
OpenAlexW3195244414

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.