Evidence map›Paper›PMID 34502064›Full record

ArticleInternational journal of molecular sciences2021

Zebrafish as a Model to Evaluate a CRISPR/Cas9-Based Exon Excision Approach as a Future Treatment Option for

Renske Schellens, Erik de Vrieze, Pam Graave, Sanne Broekman, Kerstin Nagel-Wolfrum, Theo Peters, Hannie Kremer, Rob W J Collin, Erwin van Wijk

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Genetic Landscape of Nonsyndromic Retinitis Pigmentosa in Portugal.Advances in experimental medicine and biology · 2025
    Review
  3. Review
  4. Article
  5. Disruption of theFrontiers in cell and developmental biology · 2023
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Renske SchellensDepartment of Otorhinolaryngology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0002-3575-1301
Erik de VriezeDepartment of Otorhinolaryngology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0003-3448-3269
Pam GraaveDepartment of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Sanne BroekmanDepartment of Otorhinolaryngology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Kerstin Nagel-WolfrumInstitute for Molecular Physiology, Johannes Gutenberg-University Mainz, 55099 Mainz, Germany.
Theo PetersDepartment of Otorhinolaryngology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Hannie KremerDepartment of Otorhinolaryngology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0002-0841-8693
Rob W J CollinDonders Institute for Brain Cognition and Behaviour, 6500 GL Nijmegen, The Netherlands.ORCID 0000-0003-4347-6503
Erwin van WijkDepartment of Otorhinolaryngology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0002-5702-3460
Radboud University Nijmegen · NLJohannes Gutenberg University Mainz · DE

Funding

Deutsche Forschungsgemeinschaft SPP2127: NA 1398/1-1Foundation Fighting Blindness PPA-0517-0717-RAD
6 · The paper itself

Abstract

Retinitis pigmentosa (RP) is an inherited retinal disease (IRD) with an overall prevalence of 1 in 4000 individuals. Mutations in

Indexed as

Disease Models, AnimalAnimalsCRISPR-Cas SystemsExonsEye ProteinsGenetic TherapyPhenotypeProtein DomainsRetinitis PigmentosaZebrafishZebrafish ProteinsEye ProteinsEYS protein, zebrafishZebrafish Proteinsantisense oligonucleotidesCRISPR/Cas9exon skipping therapyEYSphotoreceptorsretinitis pigmentosazebrafish

Identifiers

PMID34502064
PMCPMC8431288
OpenAlexW3196085166

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.