Evidence map›Paper›PMID 34502040›Full record

ArticleInternational journal of molecular sciences2021

In Vitro and In Silico Evaluation of New 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-

Krzysztof Peregrym, Łukasz Szczukowski, Benita Wiatrak, Katarzyna Potyrak, Żaneta Czyżnikowska, Piotr Świątek

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-Pharmaceuticals (Basel, Switzerland) · 2025
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Bioactive Oxadiazoles 2.0.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Krzysztof PeregrymDepartment of Medicinal Chemistry, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
Łukasz SzczukowskiDepartment of Medicinal Chemistry, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.ORCID 0000-0002-9768-6269
Benita WiatrakDepartment of Pharmacology, Faculty of Medicine, Wroclaw Medical University, Mikulicza-Radeckiego 2, 50-345 Wroclaw, Poland.ORCID 0000-0002-1404-2274
Katarzyna PotyrakDepartment of Pharmacology, Faculty of Medicine, Wroclaw Medical University, Mikulicza-Radeckiego 2, 50-345 Wroclaw, Poland.
Żaneta CzyżnikowskaDepartment of Inorganic Chemistry, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.ORCID 0000-0002-5758-9667
Piotr ŚwiątekDepartment of Medicinal Chemistry, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.ORCID 0000-0003-4613-025X
Wroclaw Medical University · PL

Funding

Ministerstwo Nauki i Szkolnictwa Wyższego SUB.D070.21.094
6 · The paper itself

Abstract

Since long-term use of classic NSAIDs can cause severe side effects related mainly to the gastroduodenal tract, discovery of novel cyclooxygenase inhibitors with a safe gastric profile still remains a crucial challenge. Based on the most recent literature data and previous own studies, we decided to modify the structure of already reported 1,3,4-oxadiazole based derivatives of pyrrolo[3,4-

Indexed as

Binding SitesCell SurvivalCyclooxygenase 1Cyclooxygenase 2Cyclooxygenase InhibitorsHumansMolecular Docking SimulationOxadiazolesProtein BindingPyridazinesPyrrolesTHP-1 CellsCyclooxygenase 1Cyclooxygenase 2Cyclooxygenase InhibitorsOxadiazolesPyridazinesPyrrolespyrrolo(3,4-d)pyridazinone1,3,4-oxadiazoleanti-inflammatory activityantioxidantscyclooxygenasedouble pharmacophore approachMannich basesmolecular dockingpyridazinone

Identifiers

PMID34502040
PMCPMC8431030
OpenAlexW3195178087

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.