ArticleInternational journal of molecular sciences2021
Identifying the Main Functional Pathways Associated with Cognitive Resilience to Alzheimer's Disease.
Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- FKBP51 inhibition ameliorates neurodegeneration and motor dysfunction in the neuromelanin-SNCA mouse model of Parkinson's disease.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- LOU/c/jall rat as a model of resilience in the context of streptozotocin-induced cognitive impairment.Frontiers in aging neuroscience · 2025Article
- Article
- Resistance and Resilience to Alzheimer's Disease.Cold Spring Harbor perspectives in medicine · 2024Review
- Genotype- and sex-specific changes in vital parameters during isoflurane anesthesia in a mouse model of Alzheimer's disease.Frontiers in medicine · 2024Article
- Mitochondria-Related Candidate Genes and Diagnostic Model to Predict Late-Onset Alzheimer's Disease and Mild Cognitive Impairment.Journal of Alzheimer's disease : JAD · 2024Article
- Molecular Mechanisms for Changing Brain Connectivity in Mice and Humans.International journal of molecular sciences · 2023Article
- A framework of transient hypercapnia to achieve an increased cerebral blood flow induced by nasal breathing during aerobic exercise.Cerebral circulation - cognition and behavior · 2023Review
- Docosahexaenoic Acid Ameliorates Contextual Fear Memory Deficits in the Tg2576 Alzheimer's Disease Mouse Model: Cellular and Molecular Correlates.Pharmaceutics · 2022Article
- Molecular Mechanisms of Alzheimer's Disease III.International journal of molecular sciences · 2022Article
- Motion, Relation, and Passion in Brain Physiological and Cognitive Aging.Brain sciences · 2022Article
- Translational approaches to understanding resilience to Alzheimer's disease.Trends in neurosciences · 2022Review
- Negative interpretation of ambiguous bodily symptoms among illness-anxious individuals: Exploring the role of developmental and maintenance constructs.Frontiers in psychiatry · 2022Article
- Integrated analysis and identification of hub genes as novel biomarkers for Alzheimer's disease.Frontiers in aging neuroscience · 2022Article
- Exploring causal links between brain functional networks and neurodegenerative disease risk using Mendelian randomization.Journal of Alzheimer's disease reportsArticle
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Understanding the mechanisms involved in cognitive resilience in Alzheimer's disease (AD) represents a promising strategy to identify novel treatments for dementia in AD. Previous findings from our group revealed that the study of aged-Tg2576 cognitive resilient individuals is a suitable tool for this purpose. In the present study, we performed a transcriptomic analysis using the prefrontal cortex of demented and resilient Tg2576 transgenic AD mice. We have been able to hypothesize that pathways involved in inflammation, amyloid degradation, memory function, and neurotransmission may be playing a role on cognitive resilience in AD. Intriguingly, the results obtained in this study are suggestive of a reduction of the influx of peripheral immune cells into the brain on cognitive resilient subjects. Indeed,
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