ArticleInternational journal of environmental research and public health2021
Combined Multimorbidity and Polypharmacy Patterns in the Elderly: A Cross-Sectional Study in Primary Health Care.
Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- A systematic review and meta-analysis of disease clusters in multimorbidity.Nature communications · 2025Pooled it
- Prevalence and impact of polypharmacy in older patients with type 2 diabetes.Aging clinical and experimental research · 2022Pooled it
- Trial
- Lifespan approaches for the prevention and management of steatotic liver disease.Nature reviews. Gastroenterology & hepatology · 2026Review
- Analytical approaches for medication management for patient safety: a scoping review.npj health systems · 2025Article
- Access to and Use of Health Services by Older Men and Women Experiencing Frailty and Ageing in Place Alone in Italy.Healthcare (Basel, Switzerland) · 2025Article
- Forecasting impact of demographic changes on the expenditures of healthcare and social security in Italy from 2022 to 2060.Archives of public health = Archives belges de sante publique · 2025Article
- Addressing Safety, Quality, and Cost of Care Through a Telehealth Outpatient Transitional Care Model: Protocol for a Pragmatic Randomized Controlled Trial.JMIR research protocols · 2025Article
- Artificial Intelligence in the Management of Polypharmacy Among Older Adults: A Scoping Review.Cureus · 2025Review
- Using electronic health records to understand multimorbidity in older people: a scoping review.European geriatric medicine · 2025Article
- Electronic Health Records: A Gateway to AI-Driven Multimorbidity Solutions-A Comprehensive Systematic Review.Journal of clinical medicine · 2025Review
- Article
- Essential New Complexity-Based Themes for Patient-Centered Diagnosis and Treatment of Dementia and Predementia in Older People: Multimorbidity and Multilevel Phenomenology.Journal of clinical medicine · 2024Review
- Maternal autoimmune disease and its association with childhood cancer: A population-based case-control study in Denmark.EJC paediatric oncology · 2024Article
- Article
- Satisfaction of people at post-working age with pharmacists' health promotion in Poland.BMC public health · 2024Article
- Multimorbidity patterns and trajectories in young and middle-aged adults: a large-scale population-based cohort study.Frontiers in public health · 2024Article
- Decision-Making in the Admission of Older Patients: A Thematic Analysis From Multiple-Stakeholder Perspectives.Cureus · 2024Article
- Multimorbidity patterns as predictors of sleeping medication use: a population-based study in women in Southern Brazil.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2024Article
- A scoping review of the clinical application of machine learning in data-driven population segmentation analysis.Journal of the American Medical Informatics Association : JAMIA · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
(1) Background: The acquisition of multiple chronic diseases, known as multimorbidity, is common in the elderly population, and it is often treated with the simultaneous consumption of several prescription drugs, known as polypharmacy. These two concepts are inherently related and cause an undue burden on the individual. The aim of this study was to identify combined multimorbidity and polypharmacy patterns for the elderly population in Catalonia. (2) Methods: A cross-sectional study using electronic health records from 2012 was conducted. A mapping process was performed linking chronic disease categories to the drug categories indicated for their treatment. A soft clustering technique was then carried out on the final mapped categories. (3) Results: 916,619 individuals were included, with 93.1% meeting the authors' criteria for multimorbidity and 49.9% for polypharmacy. A seven-cluster solution was identified: one non-specific (Cluster 1) and six specific, corresponding to diabetes (Cluster 2), neurological and musculoskeletal, female dominant (Clusters 3 and 4) and cardiovascular, cerebrovascular and renal diseases (Clusters 5 and 6), and multi-system diseases (Cluster 7). (4) Conclusions: This study utilized a mapping process combined with a soft clustering technique to determine combined patterns of multimorbidity and polypharmacy in the elderly population, identifying overrepresentation in six of the seven clusters with chronic disease and chronic disease-drug categories. These results could be applied to clinical practice guidelines in order to better attend to patient needs. This study can serve as the foundation for future longitudinal regarding relationships between multimorbidity and polypharmacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.