Evidence map›Paper›PMID 34501608›Full record

ArticleInternational journal of environmental research and public health2021

Sex Differences and Predictors of In-Hospital Mortality among Patients with COVID-19: Results from the ANCOHVID Multicentre Study.

Nicolás Francisco Fernández-Martínez, Rocío Ortiz-González-Serna, Álvaro Serrano-Ortiz, Mario Rivera-Izquierdo, Rafael Ruiz-Montero, Marina Pérez-Contreras, Inmaculada Guerrero-Fernández de Alba, Álvaro Romero-Duarte, Inmaculada Salcedo-Leal

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Observational
  7. Observational
  8. Article
  9. COVID-19 and the Vasculature: Current Aspects and Long-Term Consequences.Frontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Nicolás Francisco Fernández-MartínezUnidad de Gestión Clínica Interniveles de Prevención, Promoción y Vigilancia de la Salud, Hospital Universitario Reina Sofía, 14004 Córdoba, Spain.ORCID 0000-0001-8257-4304
Rocío Ortiz-González-SernaUnidad de Gestión Clínica Interniveles de Prevención, Promoción y Vigilancia de la Salud, Hospital Universitario Reina Sofía, 14004 Córdoba, Spain.
Álvaro Serrano-OrtizUnidad de Gestión Clínica Interniveles de Prevención, Promoción y Vigilancia de la Salud, Hospital Universitario Reina Sofía, 14004 Córdoba, Spain.ORCID 0000-0003-2502-0254
Mario Rivera-IzquierdoService of Preventive Medicine and Public Health, Hospital Universitario Clínico San Cecilio, 18016 Granada, Spain.
Rafael Ruiz-MonteroUnidad de Gestión Clínica Interniveles de Prevención, Promoción y Vigilancia de la Salud, Hospital Universitario Reina Sofía, 14004 Córdoba, Spain.ORCID 0000-0002-9113-6493
Marina Pérez-ContrerasService of Preventive Medicine and Public Health, Hospital Universitario de Puerto Real, 11510 Puerto Real, Spain.ORCID 0000-0003-1715-9512
Inmaculada Guerrero-Fernández de AlbaService of Preventive Medicine and Public Health, Hospital Universitario Clínico San Cecilio, 18016 Granada, Spain.ORCID 0000-0002-9082-6257
Álvaro Romero-DuarteSchool of Medicine, University of Granada, 18016 Granada, Spain.
Inmaculada Salcedo-LealUnidad de Gestión Clínica Interniveles de Prevención, Promoción y Vigilancia de la Salud, Hospital Universitario Reina Sofía, 14004 Córdoba, Spain.ORCID 0000-0002-0864-6856
Instituto Maimónides de Investigación Biomédica de Córdoba · ESUniversidad de Granada · ESHospital Universitario Puerto Real · ESInstituto de Investigación Biosanitaria de Granada · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spain is one of the countries most affected by the COVID-19 pandemic. Although risk factors for severe disease are published, sex differences have been widely neglected. In this multicentre study, we aimed to identify predictors of in-hospital mortality in men and women hospitalised with COVID-19. An observational longitudinal study was conducted in the cohort of patients admitted to four hospitals in Andalusia, Spain, from 1 March 2020 to 15 April 2020. Sociodemographic and clinical data were collected from hospital records. The Kaplan-Meier method was used to estimate 30-day survival and multiple Cox regression models were applied. All analyses were stratified by sex. A total of 968 patients were included (54.8% men, median age 67.0 years). In-hospital mortality reached 19.1% in men and 16.0% in women. Factors independently associated with an increased hazard of death were advanced age, higher CURB-65 score and not receiving azithromycin treatment, in both sexes; active cancer and autoimmune disease, in men; cardiovascular disease and chronic lung disease, in women. Disease outcomes and predictors of death differed between sexes. In-hospital mortality was higher in men, but the long-term effects of COVID-19 merit further research. The sex-differential impact of the pandemic should be addressed in public health policies.

Indexed as

COVID-19PandemicsAgedFemaleHospitalizationHospital MortalityHumansLongitudinal StudiesMaleRetrospective StudiesRisk FactorsSARS-CoV-2Sex CharacteristicsCOVID-19hospital mortalityrisk factorsSARS-CoV-2sex

Identifiers

PMID34501608
PMCPMC8431708
OpenAlexW3194135112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.