SynthesisInternational journal of environmental research and public health2021
Current Update on the Clinical Utility of MMSE and MoCA for Stroke Patients in Asia: A Systematic Review.
Synthesis in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- MoCA and MMSE for the detection of post-stroke cognitive impairment: a comparative diagnostic test accuracy systematic review and meta‑analysis.Journal of neurology · 2025Pooled it
- Comparative efficacy of non-invasive brain stimulation for post-stroke cognitive impairment: a network meta-analysis.Aging clinical and experimental research · 2024Pooled it
- The impact of transcranial direct current stimulation on brain network connectivity and topology in post-stroke cognitive impairment patients: a resting-state fMRI study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Trial
- Dual-tDCS combined with sensorimotor training promotes upper limb function in subacute stroke patients: A randomized, double-blinded, sham-controlled study.CNS neuroscience & therapeutics · 2024Trial
- Comparison of a single session of tDCS on cerebellum vs. motor cortex in stroke patients: a randomized sham-controlled trial.Annals of medicine · 2023Trial
- Do Current Endpoints Underestimate Benefit in MeVO Stroke? A Call for Cognitive Profiling.Clinical neuroradiology · 2026Article
- Diagnostic accuracy of drawing tests and their combinations for post-stroke cognitive impairment in patients with lower education.BMC neurology · 2026Article
- Research on Threshold Optimization and Variability-Based Digital Biomarker Approaches Through MMSE-Lifelog Multimodal Integrated Analysis from a Clinical Screening Perspective.Healthcare (Basel, Switzerland) · 2026Article
- Advancing clinical trial readiness in white matter disease and related dementias: key steps for future research progress.GeroScience · 2026Article
- Earlier first-time memory clinic visits during the COVID-19 pandemic: A comparison of dementia severity and caregiver burden.Journal of family medicine and primary care · 2026Article
- Dynamic trajectories of inflammatory biomarkers and post-stroke cognitive impairment: a comprehensive review of neuroimmune mechanisms, longitudinal modeling, and clinical translation.Frontiers in neurology · 2026Review
- Effects of intraoperative hypercapnia on postoperative brain functional network connectivity and cognitive function in adult patients undergoing Clipping Intracranial Aneurysm.BMC neurology · 2025Article
- Article
- The Use of Repetitive Transcranial Magnetic Stimulation to Improve Cognitive Impairment in Patients With Stroke Based on rs-fMRI Findings: Protocol for a Meta-Analysis.JMIR research protocols · 2025Article
- Assessing the link between cerebellar volume and cognitive function in Alzheimer's disease: a pilot study.Scientific reports · 2025Article
- The East London Parkinson's disease project - a case-control study of Parkinson's Disease in a diverse population.NPJ Parkinson's disease · 2025Article
- Cognitive Outcome in Patients with Middle Cerebral Artery and Anterior Cerebral Artery Territory Ischaemic Stroke at a Tertiary Health Care Centre.Annals of neurosciences · 2025Article
- Article
- Leveraging machine learning for precision medicine: a predictive model for cognitive impairment in cholestasis patients.BMC gastroenterology · 2025Article
- Adaptation of Oxford Cognitive Screen into Turkish (OCS-TR): Validity and reliability study in stroke survivors.BMC psychology · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePrimary care clinicians in Asia employed the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) to aid dementia diagnosis post-stroke. Recent studies questioned their clinical utility in stroke settings for relying on verbal abilities and education level, as well as lack of consideration for aphasia and neglect. We aimed to review the clinical utility of the MMSE and MoCA for stroke patients in Asia and provide recommendations for clinical practice.
methodsPubMed, Scopus, Web of Science, and Science Direct were searched for relevant articles. Included studies were assessed for risk of bias. RevMan 5.4 was used for data synthesis (sensitivity and specificity) and covariates were identified.
resultsAmong the 48 full-text articles reviewed, 11 studies were included with 3735 total subjects; of these studies, 7 (77%) were conducted in China, 3 (27%) in Singapore, and 1 (9%) in South Korea. Both the MMSE and MoCA generally showed adequate sensitivity and specificity. Education was identified as a covariate that significantly affected detection accuracy. Due to heterogeneity in cutoff scores, methodologies, and languages, it was not feasible to suggest a single cutoff score. One additional point is recommended for MoCA for patients with <6 years of education.
conclusionClinicians in Asia are strongly recommended to consider the education level of stroke patients when interpreting the results of the MMSE and MoCA. Further studies in other Asian countries are needed to understand their clinical value in stroke settings.
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