Evidence map›Paper›PMID 34501529›Full record

ArticleInternational journal of environmental research and public health2021

Assessment of Severe COVID-19 Outcomes Using Measures of Smoking Status and Smoking Intensity.

E Melinda Mahabee-Gittens, Angelico Mendy, Ashley L Merianos

Abstract read
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Comorbidities in childhood-onset and adult-onset asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

E Melinda Mahabee-GittensDivision of Emergency Medicine, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.ORCID 0000-0002-3893-885X
Angelico MendyDivision of Epidemiology, Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Ashley L MerianosSchool of Human Services, University of Cincinnati, Cincinnati, OH 45221, USA.ORCID 0000-0002-5640-7227

Funding

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI PINNEY, SUSAN MENGEL · 1992 to 2022
$35.4M
Supplement: Contribution of Thirdhand Smoke to Overall Tobacco SmokeR01ES027815 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI MAHABEE-GITTENS, E. MELINDA, MATT, GEORG E · 2018 to 2022
$3.1M
Prevalence and Clinical Correlates of Thirdhand Smoke Exposure in a Pediatric Patient PopulationR01ES030743 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI MAHABEE-GITTENS, E. MELINDA · 2019 to 2023
$2.9M
Reducing Secondhand Smoke Exposure Among Pediatric Patients in the Emergency Department SettingK01DA044313 · NIDA · UNIVERSITY OF CINCINNATI · PI MERIANOS, ASHLEY L · 2017 to 2021
$727k
Distinguishing Exposure to Secondhand and Thirdhand Tobacco Smoke and Electronic Cigarettes among U.S. Children based on Multiple Biomarker ProfilesR21ES032161 · NIEHS · UNIVERSITY OF CINCINNATI · PI MERIANOS, ASHLEY L · 2020 to 2021
$467k
NIDA NIH HHS K01 DA044313NIDA NIH HHS K01DA044313NIEHS NIH HHS P30 ES006096NIEHS NIH HHS R01 ES027815NIEHS NIH HHS R01 ES030743NIEHS NIH HHS R01ES030743, R01ES027815, R21ES032161, P30ES006096NIEHS NIH HHS R21 ES032161
6 · The paper itself

Abstract

objectiveSmoking status does not indicate the amount or length of tobacco use, and thus, it is an imperfect measure to assess the association between cigarette smoking and severe coronavirus disease 2019 (COVID-19) outcomes. This investigation assessed whether cigarette smoking status, intensity of smoking (i.e., average daily packs of cigarettes smoked), duration of smoking, and pack-years of smoking are associated with severe outcomes among adults diagnosed with COVID-19.

methodsWe conducted a retrospective, cross-sectional study in which we identified consecutive patients diagnosed with COVID-19 at the University of Cincinnati healthcare system between 13 March 2020 and 30 September 2020 who had complete information on smoking status, severe COVID-19 outcomes, and covariates (i.e., demographics and comorbidities). We used logistic regression to evaluate the associations of smoking status and intensity of smoking with COVID-19 severity, defined as hospitalization, admission to intensive care unit (ICU), or death, adjusting for sociodemographics and comorbidities.

resultsAmong the 4611 COVID-19 patients included in the analysis, 18.2% were current smokers and 20.7% were former smokers. The prevalence of COVID-19 outcomes was 28.9% for hospitalization, 9.8% for ICU admission, and 1.4% for death. In the adjusted analysis, current smoking (AOR: 1.23, 95% CI: 1.02-1.49), former smoking (AOR: 1.28, 95% CI: 1.07-1.54), and pack-years of smoking (AOR: 1.09, 95% CI: 1.02-1.17) were associated with a higher prevalence of hospitalization. Average daily packs of cigarettes smoked was associated with a higher prevalence of hospitalization (AOR: 1.30, 95% CI: 1.10-1.53) and ICU admission (AOR: 1.23, 95% CI: 1.04-1.44).

conclusionsSmoking status, pack-years, and intensity of smoking were associated with hospitalizations in patients with COVID-19 and intensity of smoking was associated with ICU admission. The findings underscore the need for detailed information beyond smoking status when evaluating smokers with COVID-19 so that the potential for adverse sequelae may be optimally managed in at-risk patients.

Indexed as

COVID-19AdultCross-Sectional StudiesHospitalizationHumansRetrospective StudiesSARS-CoV-2SmokingCOVID-19hospitalizationintensive care unitsmokingtobacco use

Identifiers

PMID34501529
PMCPMC8431679

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.