ReviewJournal of clinical medicine2021
Fatigue in Systemic Lupus Erythematosus: An Update on Its Impact, Determinants and Therapeutic Management.
Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Effects of exercise interventions on core health outcomes in patients with SLE: systematic review and meta-analysis.Lupus science & medicine · 2026Pooled it
- Persistent symptom burden in long-standing systemic lupus erythematosus: a subgroup-focused hypothesis for an SLE-ME/CFS research phenotype.Journal of translational medicine · 2026Article
- Measurement properties of the FATIGUE-PRO in patients with SLE in real-world settings.Lupus science & medicine · 2026Observational
- Fatigue beyond inflammation in inflammatory rheumatic diseases: a narrative review and treatable-traits framework.Rheumatology international · 2026Review
- Understanding Health-related quality of life in rheumatologic diseases: insights from PROMISJournal of patient-reported outcomes · 2026Article
- Mental health monitoring in adolescents with SLE: associations with lupus low disease activity state and remission.Lupus science & medicine · 2026Article
- Stress exposure prior to diagnosis and clinical characteristics in systemic lupus erythematosus: a cross-sectional study.Rheumatology international · 2026Article
- Efficacy of belimumab in patients with SLE and haematological manifestations: retrospective analysis from the BeRLiSS 2.0 cohort.Lupus science & medicine · 2026Article
- Navigating uncertainty: Experience of individuals living with systemic lupus erythematosus.BMC rheumatology · 2026Article
- Inverse association between hydroxychloroquine use and depressive symptoms in systemic lupus erythematosus: a single-center cross-sectional study.BMC rheumatology · 2026Article
- Mobility, sleep quality, depression and anxiety as correlates of fatigue in childhood-onset systemic lupus erythematosus.Frontiers in immunology · 2026Article
- Clinical and Psychosocial Predictors of Physical Activity in Systemic Lupus Erythematosus: A Multicentre Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2025Article
- "My world has shrunk": a mixed-methods exploration of the impact of systemic autoimmune rheumatic diseases on patients' lives.Rheumatology international · 2025Article
- Brain perfusion and blood-brain barrier permeability in systemic lupus erythematosus patients: Associations with disease activity, cognitive dysfunction, fatigue and pain.Neuroimage. Reports · 2025Article
- Neuropsychiatric symptoms in systemic lupus erythematosus: mixed methods analysis of patient-derived attributional evidence in the international INSPIRE project.Rheumatology (Oxford, England) · 2025Article
- Exploring the influence of social support, disease activity, and fibromyalgia on the emotional well-being of women with systemic lupus erythematosus.BMC rheumatology · 2025Article
- Fatigue and associated factors among patients with systemic lupus erythematosus in China: a cross-sectional study.Frontiers in medicine · 2025Article
- Which fatigue scale should I use? A Rasch analysis of two fatigue scales in inflammatory conditions.Rheumatology (Oxford, England) · 2025Article
- Review
- The NYMERIA Study: A Real-World, Multicentre Contemporary Assessment of Disease- and Patient-Related Burden and Treatment Strategies in Patients with Systemic Lupus Erythematosus.Mediterranean journal of rheumatology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Fatigue is a complex and multifactorial phenomenon which is often neglected by clinicians. The aim of this review was to analyze the impact, determinants and management of fatigue in patients with Systemic Lupus Erythematosus (SLE). Fatigue is one of the most prevalent symptoms in SLE, reported by 67% to 90% of patients. It is also described as the most bothersome symptom, considering that it may impair key aspects of health-related quality of life, while also leading to employment disability. It is a multifactorial phenomenon involving psychological factors, pain, lifestyle factors such as reduced physical activity, whereas the contribution of disease activity remains controversial. The management of fatigue in patients with SLE should rely upon a person-centered approach, with targeted interventions. Some pharmacological treatments used to control disease activity have demonstrated beneficial effects upon fatigue and non-pharmacological therapies such as psychological interventions, pain reduction and lifestyle changes, and each of these should be incorporated into fatigue management in SLE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.