Evidence map›Paper›PMID 34501433›Full record

ArticleJournal of clinical medicine2021

Genetics Variants in the Epoxygenase Pathway of Arachidonic Metabolism Are Associated with Eicosanoids Levels and the Risk of Diabetic Nephropathy.

Sonia Mota-Zamorano, Nicolás R Robles, Luz M González, José M Valdivielso, Juan Lopez-Gomez, Bárbara Cancho, Guadalupe García-Pino, Guillermo Gervasini

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sonia Mota-ZamoranoDepartment of Medical and Surgical Therapeutics, Division of Pharmacology, Medical School, University of Extremadura, 06071 Badajoz, Spain.
Nicolás R RoblesService of Nephrology, Badajoz University Hospital, 06071 Badajoz, Spain.ORCID 0000-0003-4984-6691
Luz M GonzálezDepartment of Medical and Surgical Therapeutics, Division of Pharmacology, Medical School, University of Extremadura, 06071 Badajoz, Spain.
José M ValdivielsoVascular and Renal Translational Research Group, UDETMA, ISCIII REDinREN, IRBLleida, 25198 Lleida, Spain.ORCID 0000-0003-1343-0184
Juan Lopez-GomezService of Clinical Analyses, Badajoz University Hospital, 06071 Badajoz, Spain.
Bárbara CanchoService of Nephrology, Badajoz University Hospital, 06071 Badajoz, Spain.
Guadalupe García-PinoZafra Hospital, 8105 Zafra, Spain.
Guillermo GervasiniDepartment of Medical and Surgical Therapeutics, Division of Pharmacology, Medical School, University of Extremadura, 06071 Badajoz, Spain.
Centro de Implantología Cirugía Oral y Maxilofacial · ESUniversidad de Extremadura · ESInstituto de Salud Carlos III · ES

Funding

Instituto de Salud Carlos III PI18/00745Junta de Extremadura GR18007Junta de Extremadura IB16014
6 · The paper itself

Abstract

Genes in the epoxygenase pathway of arachidonic acid metabolism leading to vasoactive eicosanoids, mainly 20-hydroxyeicosatetraenoic (20-HETE) and epoxyeicosatrienoic (EETs) acids, have been related to glucose-induced renal damage in preclinical reports. We genotyped 1088 diabetic kidney disease (DKD) patients and controls for seven polymorphisms in five genes (

Indexed as

chronic kidney diseaseCYP4F2diabetes mellitusdiabetic kidney disease

Identifiers

PMID34501433
PMCPMC8432556
OpenAlexW3197796205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.