Evidence map›Paper›PMID 34501430›Full record

ArticleJournal of clinical medicine2021

Interstitial Lung Disease at High Resolution CT after SARS-CoV-2-Related Acute Respiratory Distress Syndrome According to Pulmonary Segmental Anatomy.

Elisa Baratella, Barbara Ruaro, Cristina Marrocchio, Natalia Starvaggi, Francesco Salton, Fabiola Giudici, Emilio Quaia, Marco Confalonieri, Maria Assunta Cova

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Elisa BaratellaDepartment of Radiology, Cattinara Hospital, University of Trieste, Strada di Fiume 447, 34128 Trieste, Italy.ORCID 0000-0002-1061-9507
Barbara RuaroDepartment of Pneumology, Cattinara Hospital, Strada di Fiume 447, 34128 Trieste, Italy.ORCID 0000-0001-8990-859X
Cristina MarrocchioDepartment of Medicine, Surgery and Health Science, University of Trieste, Strada di Fiume 447, 34128 Trieste, Italy.ORCID 0000-0003-2757-7400
Natalia StarvaggiDepartment of Medicine, Surgery and Health Science, University of Trieste, Strada di Fiume 447, 34128 Trieste, Italy.
Francesco SaltonDepartment of Pneumology, Cattinara Hospital, Strada di Fiume 447, 34128 Trieste, Italy.ORCID 0000-0002-0864-9766
Fabiola GiudiciBiostatistics Unit, Department of Medicine, Surgery and Health Sciences, Cattinara Hospital, University of Trieste, Strada di Fiume 447, 34128 Trieste, Italy.ORCID 0000-0002-4160-3479
Emilio QuaiaDepartment of Medicine-DIMED, Radiology Institute, University of Padua, Via Nicolò Giustiniani, 2, 35128 Padua, Italy.
Marco ConfalonieriDepartment of Pneumology, Cattinara Hospital, Strada di Fiume 447, 34128 Trieste, Italy.ORCID 0000-0002-4791-768X
Maria Assunta CovaDepartment of Radiology, Cattinara Hospital, University of Trieste, Strada di Fiume 447, 34128 Trieste, Italy.
University of Trieste · ITOspedale di Cattinara · ITUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe purpose of this study was to evaluate High-Resolution CT (HRCT) findings in SARS-CoV-2-related ARDS survivors treated with prolonged low-dose methylprednisolone after hospital discharge.

methodsA total of 44 consecutive patients (M: 32, F: 12, average age: 64), hospitalised in our department from April to September 2020 for SARS-CoV-2-related ARDS, who had a postdischarge CT scan, were enrolled into this retrospective study. We reviewed the electronic medical charts to collect laboratory, clinical, and demographic data. The CT findings were evaluated and classified according to lung segmental distribution. The imaging findings were correlated with spirometry results and included ground glass opacities (GGOs), consolidations, reticulations, bronchiectasis/bronchiolectasis, linear bands, and loss of pulmonary volume.

resultsAlterations in the pulmonary parenchyma were observed in 97.7% of patients at HRCT (median time lapse between ARDS diagnosis and HRCT: 2.8 months, range 0.9 to 6.7). The most common findings were linear bands (84%), followed by GGOs (75%), reticulations (34%), bronchiolectasis (32%), consolidations (30%), bronchiectasis (30%) and volume loss (25%). They had a symmetric distribution, and both lower lobes were the most affected areas.

conclusionsA reticular pattern with a posterior distribution was observed 3 months after discharge from severe COVID-19 pneumonia, and this differs from previously described postCOVID-19 fibrotic-like changes. We hypothesized that the systematic use of prolonged low-dose of corticosteroid could be the main reason of this different CT scan appearance.

Indexed as

acute respiratory distress syndromeCOVID-19 pneumoniahigh resolution computed tomographypulmonary fibrosis

Identifiers

PMID34501430
PMCPMC8432464
OpenAlexW3197653778

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.