Evidence map›Paper›PMID 34501395›Full record

ReviewJournal of clinical medicine2021

Viscoelastic Hemostatic Assays for Postpartum Hemorrhage.

Alyson E Liew-Spilger, Nikki R Sorg, Toby J Brenner, Jack H Langford, Margaret Berquist, Natalie M Mark, Spencer H Moore, Julie Mark, Sara Baumgartner, Mary P Abernathy

3 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05127642 completednot on this mapstarted 2024, after this paper: background citation

Hemostatic Assessment of Postpartum Hemorrhage Cases Using Sonoclot Signature

TypeobservationalSponsorAssiut UniversityRan2024 to 2024Enrolled90ConditionsPostpartum Hemorrhage
NCT06255002 completednot on this mapstarted 2024, after this paper: background citation

Concordance Between the Measurement of Whole Blood Fibrinogen by the qLabs®FIB Analyzer and Its Measurement by Conventional Method (Clauss Fibrinogen) in the Context of Severe Postpartum Haemorrhage: a Prospective Multicenter Non-interventional Study

TypeobservationalSponsorAssistance Publique - Hôpitaux de ParisRan2024 to 2026Enrolled70ConditionsPostpartum HemorrhageArmsFibrinogen concentration by the qLabs®FIB Monitoring system
NCT07616349 recruitingnot on this mapstarted 2026, after this paper: background citation

Prediction of Platelet Function Using Viscoelastic Test (ROTEM® Sigma) in Obstetric Anesthesia: an Prospective Observational Study

TypeobservationalSponsorNicolas BroglyRan2026 to 2027Enrolled85ConditionsThrombocytopenia, Postpartum Haemorrhage (PPH)ArmsNo Intervention: Observational Cohort
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Baseline values for QuantraBMC pregnancy and childbirth · 2025
    Observational
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. The Use of the Maximum Amplitude Parameter in Thromboelastography for Obstetric Anesthesiology: A Retrospective Study Conducted at a University Medical Center.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Alyson E Liew-SpilgerDepartment of Obstetrics and Gynecology, University of Oklahoma College of Medicine, Oklahoma City, OK 73104, USA.
Nikki R SorgIndiana University School of Medicine South Bend Campus, Notre Dame, IN 46617, USA.ORCID 0000-0002-7624-2765
Toby J BrennerDivision of Natural Sciences, Indiana Wesleyan University, Marion, IN 46953, USA.ORCID 0000-0002-5970-9730
Jack H LangfordCollege of Pharmacy and Health Sciences, Butler University, Indianapolis, IN 46208, USA.
Margaret BerquistCollege of Science, University of Notre Dame, Notre Dame, IN 46556, USA.
Natalie M MarkIndiana University School of Medicine South Bend Campus, Notre Dame, IN 46617, USA.
Spencer H MooreMarian University College of Osteopathic Medicine, Indianapolis, IN 46222, USA.
Julie MarkIndiana University School of Medicine South Bend Campus, Notre Dame, IN 46617, USA.
Sara BaumgartnerDepartment of Obstetrics and Gynecology, Saint Joseph Regional Medical Center, Mishawaka, IN 46545, USA.
Mary P AbernathyDepartment of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Indiana University School of MedicineButler University · USIndiana Wesleyan University · USMarian University - Indiana · USSt. Joseph Regional Medical Center · USUniversity of Notre Dame · USUniversity of Oklahoma · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This article discusses the importance and effectiveness of viscoelastic hemostatic assays (VHAs) in assessing hemostatic competence and guiding blood component therapy (BCT) in patients with postpartum hemorrhage (PPH). In recent years, VHAs such as thromboelastography and rotational thromboelastometry have increasingly been used to guide BCT, hemostatic adjunctive therapy and prohemostatic agents in PPH. The three pillars of identifying hemostatic competence include clinical observation, common coagulation tests, and VHAs. VHAs are advantageous because they assess the cumulative contribution of all components of the blood throughout the entire formation of a clot, have fast turnaround times, and are point-of-care tests that can be followed serially. Despite these advantages, VHAs are underused due to poor understanding of correct technique and result interpretation, a paucity of widespread standardization, and a lack of large clinical trials. These VHAs can also be used in cases of uterine atony, preeclampsia, acute fatty liver of pregnancy, amniotic fluid embolism, placental abruption, genital tract trauma, surgical trauma, and inherited and prepartum acquired coagulopathies. There exists an immediate need for a point-of-care test that can equip obstetricians with rapid results on developing coagulopathic states. The use of VHAs in predicting and treating PPH, although in an incipient state, can fulfill this need.

Indexed as

amniotic fluid embolismblood coagulationblood component transfusiondisseminated intravascular coagulationobstetricspostpartum hemorrhagepregnancyrotational thromboelastometrythromboelastographyvon Willebrand factor

Identifiers

PMID34501395
PMCPMC8432102
OpenAlexW3196943090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.