Evidence map›Paper›PMID 34501367›Full record

ArticleJournal of clinical medicine2021

Catalase Predicts In-Hospital Mortality after Out-of-Hospital Cardiac Arrest.

Anton Früh, Andrea Bileck, Besnik Muqaku, Raphael Wurm, Benjamin Neuditschko, Henrike Arfsten, Lukas Galli, Lukas Kriechbaumer, Pia Hubner, Georg Goliasch and 6 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Anton FrühDepartment of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria.
Andrea BileckDepartment of Analytical Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-7053-8856
Besnik MuqakuDepartment of Analytical Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria.
Raphael WurmDepartment of Neurology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0003-3027-7775
Benjamin NeuditschkoDepartment of Analytical Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-7024-7493
Henrike ArfstenDepartment of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-5836-7759
Lukas GalliDepartment of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria.
Lukas KriechbaumerUniversity Clinic of Orthopedics, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria.
Pia HubnerDepartment of Emergency Medicine, Medical University of Vienna, 1090 Vienna, Austria.
Georg GoliaschDepartment of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria.
Gottfried HeinzDepartment of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria.
Michael HolzerDepartment of Emergency Medicine, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-5520-5116
Fritz SterzDepartment of Emergency Medicine, Medical University of Vienna, 1090 Vienna, Austria.
Christopher AdlbrechtImed19-Privat, Private Clinical Research Center, 1190 Vienna, Austria.
Christopher GernerDepartment of Analytical Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria.ORCID 0000-0003-4964-0642
Klaus DistelmaierDepartment of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria.
Medical University of Vienna · ATUniversity of Vienna · ATParacelsus Medical University · AT

Funding

Oesterreichische Nationalbank 15959
6 · The paper itself

Abstract

The generation of harmful reactive oxygen species (ROS), including hydrogen peroxide, in out-of-hospital cardiac arrest (OHCA) survivors causes systemic ischemia/reperfusion injury that may lead to multiple organ dysfunction and mortality. We hypothesized that the antioxidant enzyme catalase may attenuate these pathophysiological processes after cardiac arrest. Therefore, we aimed to analyze the predictive value of catalase levels for mortality in OHCA survivors. In a prospective, single-center study, catalase levels were determined in OHCA survivors 48 h after the return of spontaneous circulation. Thirty-day mortality was defined as the study end point. A total of 96 OHCA survivors were enrolled, of whom 26% (

Indexed as

catalaseMRMout-of-hospital cardiac arrestsurvivaltargeted proteomics

Identifiers

PMID34501367
PMCPMC8432041
OpenAlexW3197981225

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.