Correlation between Cerebrospinal Fluid IL-12 Levels and Severity of Encephalopathy in Children.

Hisashi Kawashima, Shinichiro Morichi, Gaku Yamanaka, Hiroo Terashi, Yasuyo Kashiwagi

Open access · goldAbstract read

In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 89% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hisashi KawashimaDepartment of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo 160-0023, Japan.ORCID 0000-0003-2571-9962

Shinichiro MorichiDepartment of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo 160-0023, Japan.

Gaku YamanakaDepartment of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo 160-0023, Japan.ORCID 0000-0002-8379-7187

Hiroo TerashiDepartment of Neurology, Tokyo Medical University, Tokyo 160-0023, Japan.ORCID 0000-0001-5465-557X

Yasuyo KashiwagiDepartment of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo 160-0023, Japan.

Tokyo Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The roles of cytokines in the cerebrospinal fluid (CSF) of patients with acute encephalopathy remain unclear and controversial. In this study, the profiles of 26 cytokines and others were determined in 17 children with infection-associated neurological complications. Interleukin (IL)-12 levels were found to be high in a few of the patients. A comparison of the IL-12 levels in the CSF of patients demonstrated that IL-12 (p70) is almost always increased in those with encephalopathy. Levels of IL-12 in the CSF were highly correlated with the levels of PDGF-bb and IL-RA. IL-12 levels were found to be weakly correlated with IFN-γ levels, and strongly correlated with VEGF levels. These results demonstrate that IL-12 levels may affect the clinical symptoms of pediatric patients with encephalopathy.

Indexed as

IL-12 p70IL-7influenzaNOxVEGF

Identifiers

PMID34501321

DOI10.3390/jcm10173873

PMCPMC8432101

OpenAlexW3198668952

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.