ReviewJournal of clinical medicine2021
Novel Advances to Post-Stroke Aphasia Pharmacology and Rehabilitation.
Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Research trends in post-stroke aphasia (2004-2024): a bibliometric and visualized analysis.Frontiers in neurology · 2025Pooled it
- Comparative Efficacy of Cognitive Training for Post-Stroke Aphasia: A Systematic Review and Network Meta-Analysis.Neurorehabilitation and neural repair · 2024Pooled it
- fNIRS reveals comparable reductions in cortical hyperconnectivity following once-daily and twice-daily rTMS in poststroke aphasia.Biomedical optics express · 2026Article
- Spinal cord stimulation as a novel neuromodulation strategy for enhancing language recovery in post-stroke aphasia: a hypothesis.Frontiers in human neuroscience · 2026Article
- Active Rehabilitation Technologies for Post-Stroke Patients.Biosensors · 2025Review
- Effects of transcranial direct current stimulation on language recovery in chronic post-stroke aphasia.Current journal of neurology · 2025Article
- Effectiveness of acupuncture for post-stroke aphasia: protocol for a systematic review and meta-analysis.Frontiers in neurology · 2025Article
- Treatment of aphasia in linguistically diverse populations: current and future directions.Frontiers in psychology · 2025Review
- Characteristics and prognosis of language impairment in subcortical aphasia of acute stroke patients.Frontiers in neurology · 2025Article
- Aphasia rehabilitation: a narrative review of adjuvant techniques.Frontiers in human neuroscience · 2025Review
- A Combination of Astragaloside IV and Hydroxysafflor Yellow A Attenuates Cerebral Ischemia-Reperfusion Injury via NF-κB/NLRP3/Caspase-1/GSDMD Pathway.Brain sciences · 2024Article
- New approaches to recovery after stroke.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Review
- Synergistic effects of combined motor and language interventions on stroke rehabilitation: a holistic approach.Frontiers in human neuroscience · 2024Article
- Integrative Approaches in Acute Ischemic Stroke: From Symptom Recognition to Future Innovations.Biomedicines · 2023Review
- The development of the People with Aphasia and Other Layperson Involvement (PAOLI) framework for guiding patient and public involvement (PPI) in aphasia research.Research involvement and engagement · 2023Article
- Improved language function for post-stroke aphasia in the long term following repeated repetitive transcranial magnetic stimulation and intensive speech-language-hearing therapy: a case report.Journal of medical case reports · 2023Article
- Review
- Relationships of the arcuate fasciculus and nigrostriatal tract with language ability in intracerebral hemorrhage using a diffusion tensor imaging.Scientific reports · 2023Article
- Virtual reality technology in the rehabilitation of post-stroke cognitive impairment: an opinion article on recent findings.Frontiers in psychology · 2023Article
- Clinical study of melodic intonation therapy combined with transcranial direct current stimulation for post-stroke aphasia: a single-blind, randomized controlled trial.Frontiers in neuroscience · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aphasia is one of the most common clinical features of functional impairment after a stroke. Approximately 21-40% of stroke patients sustain permanent aphasia, which progressively worsens one's quality of life and rehabilitation outcomes. Post-stroke aphasia treatment strategies include speech language therapies, cognitive neurorehabilitation, telerehabilitation, computer-based management, experimental pharmacotherapy, and physical medicine. This review focuses on current evidence of the effectiveness of impairment-based aphasia therapies and communication-based therapies (as well as the timing and optimal treatment intensities for these interventions). Moreover, we present specific interventions, such as constraint-induced aphasia therapy (CIAT) and melodic intonation therapy (MIT). Accumulated data suggest that using transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) is safe and can be used to modulate cortical excitability. Therefore, we review clinical studies that present TMS and tDCS as (possible) promising therapies in speech and language recovery, stimulating neuroplasticity. Several drugs have been used in aphasia pharmacotherapy, but evidence from clinical studies suggest that only nootropic agents, donepezil and memantine, may improve the prognosis of aphasia. This article is an overview on the current state of knowledge related to post-stroke aphasia pharmacology, rehabilitation, and future trends.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.