ArticleMaterials (Basel, Switzerland)2021
The Characterization of Scaffolds Based on Dialdehyde Chitosan/Hyaluronic Acid.
Article in Materials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Cross-Linking Agents in Three-Component Materials Dedicated to Biomedical Applications: A Review.Polymers · 2024Review
- 3D printing tissue-engineered scaffolds for auricular reconstruction.Materials today. Bio · 2024Review
- Mesoporous silica nanoparticles with dual-targeting agricultural sources for enhanced cancer treatmentRSC advances · 2023Article
- Scaffolds Loaded with Dialdehyde Chitosan and Collagen-Their Physico-Chemical Properties and Biological Assessment.Polymers · 2022Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
In this work, two-component dialdehyde chitosan/hyaluronic acid scaffolds were developed and characterized. Dialdehyde chitosan was obtained by one-step synthesis with chitosan and sodium periodate. Three-dimensional scaffolds were prepared by the lyophilization method. Fourier transform infrared spectroscopy (FTIR) was used to observe the chemical structure of scaffolds and scanning electron microscopy (SEM) imaging was done to assess the microstructure of resultant materials. Thermal analysis, mechanical properties measurements, density, porosity and water content measurements were used to characterize physicochemical properties of dialdehyde chitosan/hyaluronic acid 3D materials. Additionally, human epidermal keratinocytes (NHEK), dermal fibroblasts (NHDF) and human melanoma cells (A375 and G-361) were used to evaluate cell viability in the presence of subjected scaffolds. It was found that scaffolds were characterized by a porous structure with interconnected pores. The scaffold composition has an influence on physicochemical properties, such as mechanical strength, thermal resistance, porosity and water content. There were no significant differences between cell viability proliferation of all scaffolds, and this observation was visible for all subjected cell lines.
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