Evidence map›Paper›PMID 34500980›Full record

ArticleMaterials (Basel, Switzerland)2021

3D Bioprinting of Biosynthetic Nanocellulose-Filled GelMA Inks Highly Reliable for Soft Tissue-Oriented Constructs.

Alexandra I Cernencu, Adriana Lungu, Diana M Dragusin, Izabela C Stancu, Sorina Dinescu, Liliana R Balahura, Paul Mereuta, Marieta Costache, Horia Iovu

Erratum issuedAbstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
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  10. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Alexandra I CernencuAdvanced Polymer Materials Group, University Politehnica of Bucharest, 011061 Bucharest, Romania.ORCID 0000-0003-4356-2612
Adriana LunguAdvanced Polymer Materials Group, University Politehnica of Bucharest, 011061 Bucharest, Romania.ORCID 0000-0003-3532-7786
Diana M DragusinAdvanced Polymer Materials Group, University Politehnica of Bucharest, 011061 Bucharest, Romania.ORCID 0000-0002-5808-0213
Izabela C StancuAdvanced Polymer Materials Group, University Politehnica of Bucharest, 011061 Bucharest, Romania.ORCID 0000-0003-0685-3947
Sorina DinescuDepartment of Biochemistry and Molecular Biology, University of Bucharest, 050095 Bucharest, Romania.ORCID 0000-0001-7196-1712
Liliana R BalahuraDepartment of Biochemistry and Molecular Biology, University of Bucharest, 050095 Bucharest, Romania.ORCID 0000-0003-1338-5280
Paul MereutaHoria Hulubei-National Institute for Physics and Nuclear Engineering (IFIN-HH), 30 Reactorului Street, 077125 Magurele, Romania.
Marieta CostacheDepartment of Biochemistry and Molecular Biology, University of Bucharest, 050095 Bucharest, Romania.ORCID 0000-0002-8103-3693
Horia IovuAdvanced Polymer Materials Group, University Politehnica of Bucharest, 011061 Bucharest, Romania.

Funding

European Regional Development Fund Competitiveness Operational Program 2014-2020, Priority axis 1, ID P_36_611, MySMIS code 107066, INOVABIOMEDRomanian Ministry of Research and Innovation, CCCDI - UEFISCDI PN-III-P1-1.2-PCCDI-2017-0782 /REGMED - project 4 TUMORthe Romanian Ministry of Education and Research, CNCS - UEFISCDI PN-III-P1-1.1-TE-2019-0787
6 · The paper itself

Abstract

Bioink-formulations based on gelatin methacrylate combined with oxidized cellulose nanofibrils are employed in the present study. The parallel investigation of the printing performance, morphological, swelling, and biological properties of the newly developed hydrogels was performed, with inks prepared using methacrylamide-modified gelatins of fish or bovine origin. Scaffolds with versatile and well-defined internal structure and high shape fidelity were successfully printed due to the high viscosity and shear-thinning behavior of formulated inks and then photo-crosslinked. The biocompatibility of 3D-scaffolds was surveyed using human adipose stem cells (hASCs) and high viability and proliferation rates were obtained when in contact with the biomaterial. Furthermore, bioprinting tests were performed with hASCs embedded in the developed formulations. The results demonstrated that the designed inks are a versatile toolkit for 3D bioprinting and further show the benefits of using fish-derived gelatin for biofabrication.

Indexed as

3D bioprinting3D nanocomposite scaffoldsbiomaterial inkscellulose nanofibrilsmethacrylamide-modified gelatin

Identifiers

PMID34500980
PMCPMC8432727

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.