ArticleMaterials (Basel, Switzerland)2021
Dissolution of Amorphous S53P4 Glass Scaffolds in Dynamic In Vitro Conditions.
Article in Materials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 19 citations in OpenAlex.
- Beyond Bioactive Glass Composition: Using Morphology to Improve In Vitro and In Vivo Performance.Advanced healthcare materials · 2025Review
- An Enhanced Bioactive Glass Composition with Improved Thermal Stability and Sinterability.Materials (Basel, Switzerland) · 2024Article
- Bioresorption and Biomineralization of S53P4 Bioactive Glass in Neutral Tris Buffer and Citric Acid Solution.ACS omega · 2024Article
- In vitro and in vivo dissolution of biocompatible S59 glass scaffolds.Journal of materials science. Materials in medicine · 2024Article
- Advanced Bioactive Glasses: The Newest Achievements and Breakthroughs in the Area.Nanomaterials (Basel, Switzerland) · 2023Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The silicate-based bioactive glass S53P4 is clinically used in bone regenerative applications in granule form. However, utilization of the glass in scaffold form has been limited by the high tendency of the glass to crystallize during sintering. Here, careful optimization of sintering parameters enabled the manufacture of porous amorphous S53P4 scaffolds with a strength high enough for surgical procedures in bone applications (5 MPa). Sintering was conducted in a laboratory furnace for times ranging from 25 to 300 min at 630 °C, i.e., narrowly below the commencement of the crystallization. The phase composition of the scaffolds was verified with XRD, and the ion release was tested in vitro and compared with granules in continuous flow of Tris buffer and simulated body fluid (SBF). The amorphous, porous S53P4 scaffolds present the possibility of using the glass composition in a wider range of applications.
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Registered trials
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