Evidence map›Paper›PMID 34500845›Full record

ArticleMolecules (Basel, Switzerland)2021

Nanoparticle-Encapsulated Camptothecin: Epigenetic Modulation in DNA Repair Mechanisms in Colon Cancer Cells.

Aisha Farhana, Avin Ee-Hwan Koh, Jia Bei Tong, Abdullah Alsrhani, Suresh Kumar Subbiah, Pooi Ling Mok

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Aisha FarhanaDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72388, Aljouf Province, Saudi Arabia.
Avin Ee-Hwan KohDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Seri Kembangan 43400, Selangor, Malaysia.
Jia Bei TongDepartment of Medical Microbiology, Universiti Putra Malaysia, Seri Kembangan 43400, Selangor, Malaysia.
Abdullah AlsrhaniDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72388, Aljouf Province, Saudi Arabia.ORCID 0000-0002-6839-8866
Suresh Kumar SubbiahDepartment of Medical Microbiology, Universiti Putra Malaysia, Seri Kembangan 43400, Selangor, Malaysia.
Pooi Ling MokDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72388, Aljouf Province, Saudi Arabia.
Universiti Putra Malaysia · MYJouf University · SA

Funding

Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia 375213500
6 · The paper itself

Abstract

Molecular crosstalk between the cellular epigenome and genome converge as a synergistic driver of oncogenic transformations. Besides other pathways, epigenetic regulatory circuits exert their effect towards cancer progression through the induction of DNA repair deficiencies. We explored this mechanism using a camptothecin encapsulated in β-cyclodextrin-EDTA-Fe

Indexed as

Antineoplastic Agents, PhytogenicApoptosisBase SequenceCamptothecinCell Line, TumorColonic NeoplasmsCyclodextrinsDNA-(Apurinic or Apyrimidinic Site) LyaseDNA-Binding ProteinsDNA Polymerase IIIDNA RepairDrug CompoundingDrug LiberationEpigenesis, GeneticGene Expression RegulationGene LibraryAntineoplastic Agents, PhytogenicAPEX1 protein, humanCamptothecinCyclodextrinsDNA-(Apurinic or Apyrimidinic Site) LyaseDNA-Binding ProteinsDNA Polymerase IIIHMGB1 ProteinNanocapsulesNucleoproteinsPOLE3 protein, humancolon cancerDNA repairepigenetic modulationnanoparticlestranscriptome analysis

Identifiers

PMID34500845
PMCPMC8434408
OpenAlexW3197577421

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.