Evidence map›Paper›PMID 34500817›Full record

ArticleMolecules (Basel, Switzerland)2021

Synthesis of Platinum(II) N-Heterocyclic Carbenes Based on Adenosine.

Maria Inês P S Leitão, Giulia Francescato, Clara S B Gomes, Ana Petronilho

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maria Inês P S LeitãoITQB-NOVA-Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Avd da Republica, 2780-157 Oeiras, Portugal.
Giulia FrancescatoITQB-NOVA-Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Avd da Republica, 2780-157 Oeiras, Portugal.ORCID 0000-0002-9199-130X
Clara S B GomesLAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.ORCID 0000-0003-3672-0045
Ana PetronilhoITQB-NOVA-Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Avd da Republica, 2780-157 Oeiras, Portugal.

Funding

Fundação para a Ciência e a Tecnologia IF/00109/2014/CP1244/CT0007Fundação para a Ciência e a Tecnologia PD/BD/135483/2018Fundação para a Ciência e a Tecnologia RECI/BBB-BEP/0124/2012Fundação para a Ciência e a Tecnologia SFRH/BD/1444412019Fundação para a Ciência e a Tecnologia UIDB/04612/2020Fundação para a Ciência e a Tecnologia UIDB/50006/2020, UIDP/50006/2020, UIDB/04378/2020, UIDP/04378/2020Fundação para a Ciência e a Tecnologia UIDP/04612/2020
6 · The paper itself

Abstract

Organometallic derivatization of nucleosides is a highly promising strategy for the improvement of the therapeutic profile of nucleosides. Herein, a methodology for the synthesis of metalated adenosine with a deprotected ribose moiety is described. Platinum(II) N-heterocyclic carbene complexes based on adenosine were synthesized, namely N-heterocyclic carbenes bearing a protected and unprotected ribose ring. Reaction of the 8-bromo-2',3',5'-tri-

Indexed as

AdenosineMethaneOrganoplatinum CompoundsAdenosinecarbeneMethaneOrganoplatinum Compounds195Pt NMRadenosinecis-influenceN-heterocyclic carbenesorganometallic nucleosidesplatinum complexes

Identifiers

PMID34500817
PMCPMC8433631

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.