Evidence map›Paper›PMID 34500764›Full record

ArticleMolecules (Basel, Switzerland)2021

Structural Insights and Docking Analysis of Adamantane-Linked 1,2,4-Triazole Derivatives as Potential 11β-HSD1 Inhibitors.

Doaa A Osman, Mario A Macías, Lamya H Al-Wahaibi, Nora H Al-Shaalan, Luke S Zondagh, Jacques Joubert, Santiago Garcia-Granda, Ali A El-Emam

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 5 countries.

Doaa A OsmanDepartment of Physical and Analytical Chemistry, Faculty of Chemistry, Oviedo University-CINN, 33006 Oviedo, Spain.
Mario A MacíasCrystallography and Chemistry of Materials, CrisQuimMat, Department of Chemistry, Universidad de Los Andes, Carrera 1 No. 18A-10, Bogotá 111711, Colombia.
Lamya H Al-WahaibiDepartment of Chemistry, College of Sciences, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.
Nora H Al-ShaalanDepartment of Chemistry, College of Sciences, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.
Luke S ZondaghPharmaceutical Chemistry, School of Pharmacy, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa.ORCID 0000-0002-1158-1555
Jacques JoubertPharmaceutical Chemistry, School of Pharmacy, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa.ORCID 0000-0003-0378-7091
Santiago Garcia-GrandaDepartment of Physical and Analytical Chemistry, Faculty of Chemistry, Oviedo University-CINN, 33006 Oviedo, Spain.ORCID 0000-0002-2373-0247
Ali A El-EmamDepartment of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.ORCID 0000-0002-9325-9497
Princess Nourah bint Abdulrahman University · SAUniversidad de Oviedo · ESUniversity of the Western Cape · ZAMansoura University · EGUniversidad de Los Andes · CO

Funding

Deanship of Scientific Research at Princess Nourah bint Abdulrahman University Grant No. RGP-1442-0010-4
6 · The paper itself

Abstract

The solid-state structural analysis and docking studies of three adamantane-linked 1,2,4-triazole derivatives are presented. Crystal structure analyses revealed that compound

Indexed as

Molecular Docking Simulation11-beta-Hydroxysteroid Dehydrogenase Type 1AdamantaneCrystallography, X-RayEnzyme InhibitorsHumansMolecular StructureTriazoles11-beta-Hydroxysteroid Dehydrogenase Type 11,2,4-triazoleAdamantaneEnzyme InhibitorsTriazoles11β-HSD1 inhibitors1,2,4-triazoleadamantaneADMEHirshfeld surface analysismolecular dockingsingle crystal X-ray

Identifiers

PMID34500764
PMCPMC8433897
OpenAlexW3198616422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.