Evidence map›Paper›PMID 34500749›Full record

ArticleMolecules (Basel, Switzerland)2021

Imidazopyridazine Acetylcholinesterase Inhibitors Display Potent Anti-Proliferative Effects in the Human Neuroblastoma Cell-Line, IMR-32.

Rakesh Kumar Sharma, Manisha Singh, Khagendra Ghimeray, Pinky Juneja, Gagan Dev, Sridhar Pulavarthi, Sabbasani Rajasekhara Reddy, Ravi Shankar Akundi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Rakesh Kumar SharmaNeuroinflammation Research Laboratory, Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi 110021, India.
Manisha SinghNeuroinflammation Research Laboratory, Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi 110021, India.
Khagendra GhimerayNeuroinflammation Research Laboratory, Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi 110021, India.ORCID 0000-0002-2698-4488
Pinky JunejaNeuroinflammation Research Laboratory, Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi 110021, India.
Gagan DevNeuroinflammation Research Laboratory, Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi 110021, India.
Sridhar PulavarthiDepartment of Chemistry, Vellore Institute of Technology (VIT), School of Advanced Sciences, Vellore 632014, India.
Sabbasani Rajasekhara ReddyDepartment of Chemistry, Vellore Institute of Technology (VIT), School of Advanced Sciences, Vellore 632014, India.
Ravi Shankar AkundiNeuroinflammation Research Laboratory, Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi 110021, India.ORCID 0000-0003-3782-5965
South Asian University · INVellore Institute of Technology University · IN

Funding

Council of Scientific and Industrial Research, India 37(1702)/17/EMR-IIScience and Engineering Research Board EMR/2016/001442
6 · The paper itself

Abstract

Imidazo[1,2-

Indexed as

AcetylcholinesteraseAntineoplastic AgentsApoptosisCell MovementCell ProliferationCell SurvivalCholinesterase InhibitorsDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular StructureNeuroblastomaOxidative StressPyridazinesStructure-Activity RelationshipTumor Cells, CulturedAcetylcholinesteraseAntineoplastic AgentsCholinesterase InhibitorspyridazinePyridazinesacetylcholinesteraseanticancer drugscell proliferationcyclooxygenasecytotoxicityimidazopyridazineinflammation

Identifiers

PMID34500749
PMCPMC8434581
OpenAlexW3196935979

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.