Evidence map›Paper›PMID 34500655›Full record

ArticleMolecules (Basel, Switzerland)2021

Unravelling the Structure of the Tetrahedral Metal-Binding Site in METP3 through an Experimental and Computational Approach.

Salvatore La Gatta, Linda Leone, Ornella Maglio, Maria De Fenza, Flavia Nastri, Vincenzo Pavone, Marco Chino, Angela Lombardi

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  6. Review
  7. Turn-Adopting Peptidomimetic as a Formyl Peptide Receptor-1 Antagonist.ACS pharmacology & translational science · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Salvatore La GattaDepartment of Chemical Sciences, University of Napoli Federico II, Via Cintia, 80126 Napoli, Italy.ORCID 0000-0003-0005-5557
Linda LeoneDepartment of Chemical Sciences, University of Napoli Federico II, Via Cintia, 80126 Napoli, Italy.ORCID 0000-0001-7293-1814
Ornella MaglioDepartment of Chemical Sciences, University of Napoli Federico II, Via Cintia, 80126 Napoli, Italy.ORCID 0000-0002-7829-1907
Maria De FenzaDepartment of Chemical Sciences, University of Napoli Federico II, Via Cintia, 80126 Napoli, Italy.ORCID 0000-0002-2856-5615
Flavia NastriDepartment of Chemical Sciences, University of Napoli Federico II, Via Cintia, 80126 Napoli, Italy.ORCID 0000-0002-3390-9822
Vincenzo PavoneDepartment of Chemical Sciences, University of Napoli Federico II, Via Cintia, 80126 Napoli, Italy.ORCID 0000-0001-6432-0802
Marco ChinoDepartment of Chemical Sciences, University of Napoli Federico II, Via Cintia, 80126 Napoli, Italy.ORCID 0000-0002-0436-3293
Angela LombardiDepartment of Chemical Sciences, University of Napoli Federico II, Via Cintia, 80126 Napoli, Italy.ORCID 0000-0002-2013-3009
University of Naples Federico II · ITInstitute of Biostructure and Bioimaging · IT

Funding

Programma Operativo Nazionale Ricerca e Competitività PON02_00029
6 · The paper itself

Abstract

Understanding the structural determinants for metal ion coordination in metalloproteins is a fundamental issue for designing metal binding sites with predetermined geometry and activity. In order to achieve this, we report in this paper the design, synthesis and metal binding properties of METP3, a homodimer made up of a small peptide, which self assembles in the presence of tetrahedrally coordinating metal ions. METP3 was obtained through a redesign approach, starting from the previously developed METP molecule. The undecapeptide sequence of METP, which dimerizes to house a Cys

Indexed as

Binding SitesComputational BiologyMagnetic Resonance SpectroscopyMetalloproteinsMetalloproteinsbioinformaticsmetalloprotein modelsminiaturized proteinsNMR structurespectroscopic characterizationtetrahedral metal binding site

Identifiers

PMID34500655
PMCPMC8434281
OpenAlexW3198914378

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.