Evidence map›Paper›PMID 34500615›Full record

ArticleMolecules (Basel, Switzerland)2021

Junipers of Various Origins as Potential Sources of the Anticancer Drug Precursor Podophyllotoxin.

Diana I Ivanova, Paraskev T Nedialkov, Alexander N Tashev, Marta Olech, Renata Nowak, Yana E Ilieva, Zlatina K Kokanova-Nedialkova, Teodora N Atanasova, George Angelov, Hristo M Najdenski

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 27 citations in OpenAlex.

  1. Larvicidal Activities ofPlants (Basel, Switzerland) · 2025
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Diana I IvanovaInstitute of Chemical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.ORCID 0000-0001-5682-9713
Paraskev T NedialkovFaculty of Pharmacy, Medical University, 1000 Sofia, Bulgaria.ORCID 0000-0001-5640-6120
Alexander N TashevDepartment of Dendrology, University of Forestry, 1756 Sofia, Bulgaria.
Marta OlechDepartment of Pharmaceutical Botany, Faculty of Pharmacy, Medical University of Lublin, 20-059 Lublin, Poland.ORCID 0000-0002-2838-550X
Renata NowakDepartment of Pharmaceutical Botany, Faculty of Pharmacy, Medical University of Lublin, 20-059 Lublin, Poland.ORCID 0000-0003-4952-3147
Yana E IlievaFaculty of Pharmacy, Medical University, 1000 Sofia, Bulgaria.ORCID 0000-0001-7784-4488
Zlatina K Kokanova-NedialkovaFaculty of Pharmacy, Medical University, 1000 Sofia, Bulgaria.
Teodora N AtanasovaFaculty of Pharmacy, Medical University, 1000 Sofia, Bulgaria.
George AngelovInstitute of Chemical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
Hristo M NajdenskiThe Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
Bulgarian Academy of Sciences · BGMedical University of Sofia · BGMedical University of Lublin · PLUniversity of Forestry · BG

Funding

Bulgarian Science Fund DN 07/25 (2016)
6 · The paper itself

Abstract

Juniper representatives are natural sources of plenty of bioactive metabolites and have been used since ancient times as folk remedies against tapeworms, warts, cancer, etc. The antiproliferative activities of junipers are attributed to podophyllotoxin (PPT), which is a precursor for the synthesis of efficient anticancer drugs. However, the natural sources of PPT,

Indexed as

Antineoplastic AgentsCell Line, TumorCell ProliferationDrugs, Chinese HerbalHT29 CellsHumansJuniperusK562 CellsLignansPlant ExtractsPlant LeavesPodophyllotoxinProdrugsAntineoplastic AgentsDrugs, Chinese HerbalLignansPlant ExtractsPodophyllotoxinProdrugscytotoxic agentsHRMSJuniperus L.LC-MSpodophyllotoxin

Identifiers

PMID34500615
PMCPMC8433965
OpenAlexW3194612305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.