Evidence map›Paper›PMID 34500594›Full record

ArticleMolecules (Basel, Switzerland)2021

Induction of G2/M Cell Cycle Arrest via p38/p21

Jih-Tung Pai, Ming-Wei Hsu, Yann-Lii Leu, Kuo-Ting Chang, Meng-Shih Weng

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 39 citations in OpenAlex.

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  6. Tubular FoxP2 and Kidney Fibrosis.Journal of the American Society of Nephrology : JASN · 2025
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  10. A perspective on tumor radiation resistance following high-LET radiation treatment.Journal of cancer research and clinical oncology · 2024
    Review
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  16. Application of Luteolin in Neoplasms and Nonneoplastic Diseases.International journal of molecular sciences · 2023
    Review
  17. Frontiers in pharmacology · 2023
    Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Jih-Tung PaiDivision of Hematology and Oncology, Tao-Yuan General Hospital, Ministry of Health and Welfare, Taoyuan City 33004, Taiwan.
Ming-Wei HsuDepartment of Nutritional Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
Yann-Lii LeuGraduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan.ORCID 0000-0002-1649-6798
Kuo-Ting ChangTranslational Medicine Center, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan City 33004, Taiwan.
Meng-Shih WengDepartment of Nutritional Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
Fu Jen Catholic University · TWChang Gung University · TWMinistry of Health and Welfare · TWTao Yuan General Hospital · TW

Funding

Taoyuan General Hospital, Ministry of Health and Welfare, Taiwan, Republic of China PTH10642 and PTH10716
6 · The paper itself

Abstract

Lung cancer is the most commonly diagnosed malignant cancer in the world. Non-small-cell lung cancer (NSCLC) is the major category of lung cancer. Although effective therapies have been administered, for improving the NSCLC patient's survival, the incident rate is still high. Therefore, searching for a good strategy for preventing NSCLC is urgent. Traditional Chinese medicine (TCM) are brilliant materials for cancer chemoprevention, because of their high biological safety and low cost. Bavachinin, which is an active flavanone of

Indexed as

A549 CellsApoptosisCarcinoma, Non-Small-Cell LungCell Cycle CheckpointsCell Line, TumorCell ProliferationCyclin B1Cyclin-Dependent Kinase Inhibitor p21FlavonesFlavonoidsG2 Phase Cell Cycle CheckpointsHumansLung NeoplasmsMAP Kinase Signaling Systemp38 Mitogen-Activated Protein KinasesSignal TransductionbavachininCyclin B1Cyclin-Dependent Kinase Inhibitor p21FlavonesFlavonoidsp38 Mitogen-Activated Protein KinasesbavachininG2/M cell cycle arrestnon-small-cell lung cancer (NSCLC)p21Waf1/Cip1p38 MAPK

Identifiers

PMID34500594
PMCPMC8434044
OpenAlexW3195124142

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.