Evidence map›Paper›PMID 34500548›Full record

ArticleMolecules (Basel, Switzerland)2021

Structural Insight into the Binding of Cyanovirin-N with the Spike Glycoprotein, M

Devashan Naidoo, Pallab Kar, Ayan Roy, Taurai Mutanda, Joseph Bwapwa, Arnab Sen, Akash Anandraj

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  6. Engineering recombinantly expressed lectin-based antiviral agents.Frontiers in cellular and infection microbiology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Devashan NaidooCentre for Algal Biotechnology, Mangosuthu University of Technology, P.O. Box 12363, Durban 4026, South Africa.ORCID 0000-0001-5843-1362
Pallab KarBioinformatics Facility, Department of Botany, University of North Bengal, Siliguri 734013, India.
Ayan RoyDepartment of Biotechnology, Lovely Professional University, Phagwara 144411, India.
Taurai MutandaCentre for Algal Biotechnology, Mangosuthu University of Technology, P.O. Box 12363, Durban 4026, South Africa.ORCID 0000-0002-9539-9231
Joseph BwapwaCentre for Algal Biotechnology, Mangosuthu University of Technology, P.O. Box 12363, Durban 4026, South Africa.
Arnab SenBioinformatics Facility, Department of Botany, University of North Bengal, Siliguri 734013, India.ORCID 0000-0002-2079-5117
Akash AnandrajCentre for Algal Biotechnology, Mangosuthu University of Technology, P.O. Box 12363, Durban 4026, South Africa.ORCID 0000-0002-2125-9957
Mangosuthu University of Technology · ZANorth Bengal University · INLovely Professional University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emergence of COVID-19 continues to pose severe threats to global public health. The pandemic has infected over 171 million people and claimed more than 3.5 million lives to date. We investigated the binding potential of antiviral cyanobacterial proteins including cyanovirin-N, scytovirin and phycocyanin with fundamental proteins involved in attachment and replication of SARS-CoV-2. Cyanovirin-N displayed the highest binding energy scores (-16.8 ± 0.02 kcal/mol, -12.3 ± 0.03 kcal/mol and -13.4 ± 0.02 kcal/mol, respectively) with the spike protein, the main protease (M

Indexed as

COVID-19 Drug TreatmentAntiviral AgentsBacterial ProteinsCoronavirus 3C ProteasesCoronavirus Papain-Like ProteasesCoronavirus Protease InhibitorsCOVID-19HumansMolecular Docking SimulationMolecular Dynamics SimulationProtein BindingProtein Interaction MappingSpike Glycoprotein, CoronavirusX-Ray Diffraction3C-like proteinase, SARS-CoV-2Antiviral AgentsBacterial ProteinsCoronavirus 3C ProteasesCoronavirus Papain-Like ProteasesCoronavirus Protease Inhibitorscyanovirin Npapain-like protease, SARS-CoV-2Spike Glycoprotein, Coronavirusspike protein, SARS-CoV-2cyanobacteriacyanovirin-Nmolecular dockingmolecular dynamics simulationsMprophycocyaninPLproSARS-CoV-2scytovirinspike protein

Identifiers

PMID34500548
PMCPMC8434238
OpenAlexW3194943390

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.