ArticlePsychiatry investigation2021
Cortical Thickness and Surface Area Abnormalities in Bipolar I and II Disorders.
Article in Psychiatry investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Blunted niacin skin flushing response with subtype-specific clinical associations in adolescent bipolar disorder.BMC psychiatry · 2026Article
- Integrated cortical-cognitive signatures identified by machine learning enable early detection of MCI in type 2 diabetes.Scientific reports · 2026Article
- Differences in biochemical metabolism and cognitive function between bipolar I and bipolar II disorder.BMC psychiatry · 2026Observational
- Association of polygenic risk for bipolar disorder with grey matter structure and white matter integrity in youth.Translational psychiatry · 2023Article
- The inferior frontal gyrus and familial risk for bipolar disorder.Psychoradiology · 2022Review
- Comparison of Hypomanic Symptoms Between Bipolar I and Bipolar II Disorders: A Network Perspective.Frontiers in psychiatry · 2022Article
- Common and Specific Characteristics of Adolescent Bipolar Disorder Types I and II: A Combined Cortical Thickness and Structural Covariance Analysis.Frontiers in psychiatry · 2021Article
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Authors and funding
7 authors.
Funding
Abstract
objectiveAlthough bipolar II disorder (BD II) is not simply a mitigated form of bipolar I disorder (BD I), their neurobiological differences have not been elucidated. The present study aimed to explore cortical thickness (CT) and surface area (SA) in patients with BD I and BD II and healthy controls (HCs) to investigate the shared and unique neurobiological mechanisms of BD subtypes.
methodsWe enrolled 30 and 44 patients with BD I and BD II, respectively, and 100 HCs. We evaluated CT and SA using FreeSurfer and estimated differences in CT and SA among the three groups (BD I vs. BD II vs. HC). We adjusted for age, sex, educational level, and intracranial volume as confounding factors.
resultsWe found widespread cortical thinning in the bilateral frontal, temporal, and occipital regions; cingulate gyrus; and insula in patients with BD. Alterations in SA, including increased SA of the pars triangularis and decreased SA of the insula, were noted in patients with BD. Overall, we found BD II patients demonstrated decreased SA in the right long insula compared to BD I patients.
conclusionOur results suggest that decreased SA in the right long insula is crucial for differentiating BD subtypes.
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