Evidence map›Paper›PMID 34500460›Full record

ArticleNucleic acids research2022

CancerMIRNome: an interactive analysis and visualization database for miRNome profiles of human cancer.

Ruidong Li, Han Qu, Shibo Wang, John M Chater, Xuesong Wang, Yanru Cui, Lei Yu, Rui Zhou, Qiong Jia, Ryan Traband and 6 more

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed
7.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 119 citations in OpenAlex.

  1. Article
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  7. Potential role ofBiochemistry and biophysics reports · 2026
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  11. Transcriptomic profiling of a canine malignant eyelid melanoma.Brazilian journal of veterinary medicine · 2026
    Article
  12. A competing TMPO-AS1-let-7b-5p-kinesin superfamily RNA network predicts poor lung cancer patient survival.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2026
    Article
  13. Review
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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Ruidong LiDepartment of Botany and Plant Sciences, University of California, Riverside, CA, USA.ORCID 0000-0002-4822-2898
Han QuDepartment of Botany and Plant Sciences, University of California, Riverside, CA, USA.
Shibo WangDepartment of Botany and Plant Sciences, University of California, Riverside, CA, USA.ORCID 0000-0001-5937-4718
John M ChaterDepartment of Botany and Plant Sciences, University of California, Riverside, CA, USA.
Xuesong WangDepartment of Botany and Plant Sciences, University of California, Riverside, CA, USA.
Yanru CuiCollege of Agronomy, Hebei Agricultural University, Baoding, China.
Lei YuDepartment of Botany and Plant Sciences, University of California, Riverside, CA, USA.
Rui ZhouDepartment of Botany and Plant Sciences, University of California, Riverside, CA, USA.
Qiong JiaDepartment of Botany and Plant Sciences, University of California, Riverside, CA, USA.ORCID 0000-0002-3063-2346
Ryan TrabandDepartment of Botany and Plant Sciences, University of California, Riverside, CA, USA.
Meiyue WangDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Weibo XieHubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, China.ORCID 0000-0002-2768-3572
Dongbo YuanDepartment of Urology, Guizhou Provincial People's Hospital, Guizhou, China.
Jianguo ZhuDepartment of Urology, Guizhou Provincial People's Hospital, Guizhou, China.
Wei-De ZhongDepartment of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Zhenyu JiaDepartment of Botany and Plant Sciences, University of California, Riverside, CA, USA.
University of California, Riverside · USGuizhou Provincial People's Hospital · CNHebei Agricultural University · CNHuazhong Agricultural University · CNMacau University of Science and Technology · MOStanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs), which play critical roles in gene regulatory networks, have emerged as promising diagnostic and prognostic biomarkers for human cancer. In particular, circulating miRNAs that are secreted into circulation exist in remarkably stable forms, and have enormous potential to be leveraged as non-invasive biomarkers for early cancer detection. Novel and user-friendly tools are desperately needed to facilitate data mining of the vast amount of miRNA expression data from The Cancer Genome Atlas (TCGA) and large-scale circulating miRNA profiling studies. To fill this void, we developed CancerMIRNome, a comprehensive database for the interactive analysis and visualization of miRNA expression profiles based on 10 554 samples from 33 TCGA projects and 28 633 samples from 40 public circulating miRNome datasets. A series of cutting-edge bioinformatics tools and machine learning algorithms have been packaged in CancerMIRNome, allowing for the pan-cancer analysis of a miRNA of interest across multiple cancer types and the comprehensive analysis of miRNome profiles to identify dysregulated miRNAs and develop diagnostic or prognostic signatures. The data analysis and visualization modules will greatly facilitate the exploit of the valuable resources and promote translational application of miRNA biomarkers in cancer. The CancerMIRNome database is publicly available at http://bioinfo.jialab-ucr.org/CancerMIRNome.

Indexed as

Databases, GeneticBiomarkers, TumorGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMicroRNAsNeoplasmsBiomarkers, TumorMicroRNAs

Identifiers

PMID34500460
PMCPMC8728249
OpenAlexW3198113004

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.