Evidence map›Paper›PMID 34500351›Full record

SynthesisAutonomic neuroscience : basic & clinical2021

Syncope and COVID-19 disease - A systematic review.

Raquel Falcão de Freitas, Sofia Cardoso Torres, Francisco Javier Martín-Sánchez, Adrián Valls Carbó, Giuseppe Lauria, José Pedro L Nunes

Open access · bronzeAbstract readSystematic Review
In one paragraph

Synthesis in Autonomic neuroscience : basic & clinical, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

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  15. Factors Associated with Falls During Hospitalization for Coronavirus Disease 2019 (COVID-19).Medical science monitor : international medical journal of experimental and clinical research · 2022
    Observational
  16. Spotlight on non-motor symptoms and Covid-19.International review of neurobiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Raquel Falcão de FreitasDepartment of Medicine, Faculdade de Medicina da Universidade do Porto, Porto, Portugal.
Sofia Cardoso TorresDepartment of Cardiology, Centro Hospitalar Universitário São João, Porto, Portugal.
Francisco Javier Martín-SánchezDepartments of Emergency and of Neurology, Hospital Clínico San Carlos, Madrid, Spain.
Adrián Valls CarbóDepartments of Emergency and of Neurology, Hospital Clínico San Carlos, Madrid, Spain.
Giuseppe LauriaDepartment of Biomedical and Clinical Sciences "Luigi Sacco", University of Milan, Milan, Italy.
José Pedro L NunesDepartment of Medicine, Faculdade de Medicina da Universidade do Porto, Porto, Portugal; Department of Cardiology, Centro Hospitalar Universitário São João, Porto, Portugal. Electronic address: jplnunes@med.up.pt.
Hospital Clínico San Carlos · ESHospital de São João · PTLuigi Sacco Hospital · ITUniversidade do Porto · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSyncope is not a common manifestation of COVID-19, but it may occur in this context and it can be the presenting symptom in some cases. Different mechanisms may explain the pathophysiology behind COVID-19 related syncope. In this report, we aimed to examine the current frequency and etiology of syncope in COVID-19.

methodsA systematic review across PubMed, ISI Web of Knowledge and SCOPUS was performed, according to PRISMA guidelines, in order to identify all relevant articles regarding both COVID-19 and syncope.

resultsWe identified 136 publications, of which 99 were excluded. The frequency of syncope and pre-syncope across the selected studies was 4.2% (604/14,437). Unexplained syncope was the most common type (87.9% of the episodes), followed by reflex syncope (7.8% of the cases). Orthostatic hypotension was responsible for 2.2% of the cases and syncope of presumable cardiac cause also accounted for 2.2% of cases. Arterial hypertension was present in 52.0% of syncope patients. The use of angiotensin receptor blockers or angiotensin converting enzyme inhibitors were not associated with an increased incidence of syncope (chi-square test 1.07, p 0.30), unlike the use of beta-blockers (chi-square test 12.48, p < 0.01).

conclusionSyncope, although not considered a typical symptom of COVID-19, can be associated with it, particularly in early stages. Different causes of syncope were seen in this context. A reevaluation of blood pressure in patients with COVID-19 is suggested, including reassessment of antihypertensive therapy, especially in the case of beta-blockers.

Indexed as

Autonomic Nervous System DiseasesCOVID-19HumansHypertensionSyncopeArterial hypertensionCovid-19syncope

Identifiers

PMID34500351
PMCPMC8393505
OpenAlexW3198311937

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.