ArticleJournal of colloid and interface science2022
Understanding microbeads stacking in deformable Nano-Sieve for Efficient plasma separation and blood cell retrieval.
Article in Journal of colloid and interface science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Advances in machine learning-enhanced microfluidic cell sorting.Science advances · 2025Review
- Sheath-enhanced concentration and on-chip detection of bacteria from an extremely low-concentration level.Lab on a chip · 2025Article
- Optimization Analysis of Particle Separation Parameters for a Standing Surface Acoustic Wave Acoustofluidic Chip.ACS omega · 2023Article
- Understanding the dynamics of fluid-structure interaction with an Air Deflected Microfluidic Chip (ADMC).Scientific reports · 2022Article
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Authors and funding
6 authors.
Funding
Abstract
Efficient separation of blood cells and plasma is key for numerous molecular diagnosis and therapeutics applications. Despite various microfluidics-based separation strategies having been developed, there is still a need for a simple, reliable, and multiplexing separation device that can process a large volume of blood. Here we show a microbead-packed deformable microfluidic system that can efficiently separate highly purified plasma from whole blood, as well as retrieve blocked blood cells from the device. To support and rationalize the experimental validation of the proposed device, a highly accurate model is constructed to help understand the link between the mechanical properties of the microfluidics, flow rate, and microbeads packing/leaking based on the microscope imaging and the optical coherence tomography (OCT) scanning. This deformable nano-sieve device is expected to offer a new solution for centrifuge-free diagnosis and treatment of bloodborne diseases and contribute to the design of next-generation deformable microfluidics for separation applications.
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