Evidence map›Paper›PMID 34499858›Full record

ArticleCell host & microbe2021

Changing the locks on intestinal signaling.

James M Fleckenstein, Jacob P Bitoun

Abstract read
In one paragraph

Article in Cell host & microbe, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

James M FleckensteinDepartment of Medicine, Division of Infectious Diseases, Washington University in Saint Louis, School of Medicine, 660 South Euclid Avenue, Saint Louis, MO 63110, USA; Medicine Service, Infectious Diseases, Veterans Affairs Health Care System, Saint Louis, MO 63106, USA. Electronic address: jfleckenstein@wustl.edu.
Jacob P BitounDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.

Funding

Novel Antigen Identification for an Enterotoxigenic E. coli VaccineR01AI089894 · NIAID · WASHINGTON UNIVERSITY · PI Zachary T. Berndsen, James Michael Fleckenstein · 2010 to 2026
$7.4M
Molecular Microbiology of Enterotoxigenic E. coli Pathogen-Host InteractionsR01AI126887 · NIAID · WASHINGTON UNIVERSITY · PI FLECKENSTEIN, JAMES MICHAEL · 2016 to 2020
$1.6M
The Role of STa in ETEC PathogenesisR01AI125542 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI BITOUN, JACOB P. · 2017 to 2020
$1.5M
Development of an ETEC multivalent subunit vaccine using outer membrane vesiclesR21AI190682 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI Jacob P. Bitoun · 2025 to 2026
$415k
Molecular Pathogenesis of Enterotoxigenic Escherichia coli InfectionsI01BX004825 · VA · ST. LOUIS VA MEDICAL CENTER · PI FLECKENSTEIN, JAMES MICHAEL · 2020 to 2024
–
BLRD VA I01 BX004825NIAID NIH HHS R01 AI089894NIAID NIH HHS R01 AI125542NIAID NIH HHS R01 AI126887NIAID NIH HHS R21 AI190682
6 · The paper itself

Abstract

Endogenous peptides and structurally similar bacterial heat-stable enterotoxins (ST) bind guanylate cyclase-C (GC-C), resulting in fluid homeostasis or diarrhea, respectively. In this issue of Cell Host & Microbe, Carey et al., show how bats have evolutionarily maintained homeostatic signaling while avoiding pathogenic effects of ST.

Indexed as

AnimalsBacterial ToxinsChiropteraCyclic GMPCyclic GMP-Dependent Protein Kinase Type IICystic Fibrosis Transmembrane Conductance RegulatorDiarrheaEnterocytesEnterotoxigenic Escherichia coliEnterotoxinsGuanylate CyclaseProtein BindingSignal TransductionSodium-Hydrogen ExchangersBacterial ToxinsCyclic GMPCyclic GMP-Dependent Protein Kinase Type IICystic Fibrosis Transmembrane Conductance RegulatorEnterotoxinsGuanylate CyclaseSodium-Hydrogen Exchangers

Identifiers

PMID34499858
PMCPMC8765524

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.