Evidence map›Paper›PMID 34499741›Full record

ArticleJournal of surgical oncology2021

It's more than just cancer biology: Health disparities in patients with pancreatic neuroendocrine tumors.

Patrick W Underwood, Andrea N Riner, Dan Neal, Miles E Cameron, Anastasiya Yakovenko, Sushanth Reddy, John Bart Rose, Steven J Hughes, Jose G Trevino

Abstract read
In one paragraph

Article in Journal of surgical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Patrick W UnderwoodDepartment of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA.
Andrea N RinerDepartment of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA.
Dan NealDepartment of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA.
Miles E CameronDepartment of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA.
Anastasiya YakovenkoDepartment of Surgery, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA.
Sushanth ReddyDepartment of Surgery, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA.
John Bart RoseDepartment of Surgery, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA.
Steven J HughesDepartment of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA.
Jose G TrevinoDepartment of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA.ORCID http://orcid.org/0000-0002-0265-8151

Funding

Tissue Modeling & Drug Development Shared Resources CoreU54CA233444 · NCI · UNIVERSITY OF FLORIDA · PI PAUL OKUNIEFF · 2018 to 2026
$12.1M
Training Program for Applied Research and Development in Genomic MedicineT32HG008958 · NHGRI · UNIVERSITY OF FLORIDA · PI Larisa Humma Cavallari, Stephen E. Kimmel · 2018 to 2026
$3.8M
Use of BCL-xL Proteolysis targeting chimeras to treat pancreatic cancerR01CA242003 · NCI · UNIVERSITY OF FLORIDA · PI TREVINO, JOSE G., ZHENG, GUANGRONG · 2019 to 2023
$2.6M
Joseph and Ann Matella Fund for Pancreatic Cancer ResearchNCI NIH HHS R01 CA242003NCI NIH HHS R01CA242003NCI NIH HHS U54 CA233444NCI NIH HHS U54CA233444NHGRI NIH HHS T32 HG008958
6 · The paper itself

Abstract

BACKGROUND AND

objectivesPancreatic neuroendocrine tumors (PNETs) represent a rare form of pancreatic cancer. Racial/ethnic disparities have been documented in pancreatic ductal adenocarcinoma, but health disparities have not been well described in patients with PNETs.

methodsA retrospective review of patients with PNETs in the National Cancer Database was performed for 2004-2014. Approximately 16 605 patients with PNETs and available vital status were identified. Survival was compared by race/ethnicity and socioeconomic status using Kaplan-Meier methods and Cox regression.

resultsThere were no significant differences in survival between Non-Hispanic, White; Hispanic, White; or Non-Hispanic, Black patients on univariate analysis. Kaplan-Meier analysis showed that patients from communities with lower median household income and education level had worse survival (p < 0.001). Patients age less than 65 without insurance, similarly, had worse survival (p < 0.001). Multivariable modeling found no association between race/ethnicity and risk of mortality (p = 0.37). Lower median household income and lower education level were associated with increased mortality (p < 0.001).

conclusionsUnlike most other malignancies, race/ethnicity is not associated with survival differences in patients with PNETs. Patients with lower socioeconomic status had worse survival. The presence of identifiable health disparities in patients with PNETs represents a target for intervention and opportunity to improve survival in patients with this malignancy.

Indexed as

Healthcare DisparitiesHealth Services AccessibilitySocioeconomic FactorsCarcinoma, Pancreatic DuctalCombined Modality TherapyEthnicityFemaleFollow-Up StudiesHumansMaleMiddle AgedNeuroendocrine TumorsPancreatic NeoplasmsPrognosisRetrospective StudiesSurvival Ratehealthcare disparitiesneuroendocrine carcinomapancreas cancer

Identifiers

PMID34499741
PMCPMC9121403

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.