ArticlePLoS biology2021
A 3-year evaluation of preclinicaltrials.eu reveals room for improvement in preregistration of animal studies.
Article in PLoS biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The optimal transplantation strategy of umbilical cord mesenchymal stem cells in spinal cord injury: a systematic review and network meta-analysis based on animal studies.Stem cell research & therapy · 2022Pooled it
- Preregistration of Preclinical Animal Studies as a Tool for Refinement: A Feasibility Study Comparing the German Animal Study Registry and Preclinicaltrials.eu.Animals : an open access journal from MDPI · 2026Article
- Improving the transparency of animal experiments: valuable lessons learned from a systematic analysis of registration protocols.BMC veterinary research · 2026Article
- FAIR environmental and health registry (FAIREHR)- supporting the science to policy interface and life science research, development and innovation.Frontiers in toxicology · 2023Article
- A guide to open science practices for animal research.PLoS biology · 2022Article
- Declaration of common standards for the preregistration of animal research-speeding up the scientific progress.PNAS nexus · 2022Article
- Preregistration of animal research protocols: development and 3-year overview of preclinicaltrials.eu.BMJ open science · 2022Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 2018, the first registry dedicated to preregistration of animal study protocols was launched. Despite international support, the overall number of (pre)registered protocols is still low, illustrating the need for pushing the preregistration agenda among researchers and policymakers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.