Evidence map›Paper›PMID 34499517›Full record

ArticleOrganic letters2021

Mild and Chemoselective Phosphorylation of Alcohols Using a Ψ-Reagent.

Michał Ociepa, Kyle W Knouse, David He, Julien C Vantourout, Dillon T Flood, Natalia M Padial, Jason S Chen, Brittany B Sanchez, Emily J Sturgell, Bin Zheng and 4 more

Abstract read
In one paragraph

Article in Organic letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Michał OciepaDepartment of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Kyle W KnouseDepartment of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.ORCID 0000-0001-9688-0513
David HeDepartment of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Julien C VantouroutDepartment of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.ORCID 0000-0002-0602-069X
Dillon T FloodDepartment of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Natalia M PadialDepartment of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Jason S ChenAutomated Synthesis Facility, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Brittany B SanchezAutomated Synthesis Facility, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Emily J SturgellAutomated Synthesis Facility, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Bin ZhengChemical Process Development, Bristol Myers Squibb, One Squibb Drive, New Brunswick, New Jersey 08901, United States.ORCID 0000-0002-2576-6016
Shenjie QiuChemical Process Development, Bristol Myers Squibb, One Squibb Drive, New Brunswick, New Jersey 08901, United States.
Michael A SchmidtChemical Process Development, Bristol Myers Squibb, One Squibb Drive, New Brunswick, New Jersey 08901, United States.ORCID 0000-0002-4880-2083
Martin D EastgateChemical Process Development, Bristol Myers Squibb, One Squibb Drive, New Brunswick, New Jersey 08901, United States.ORCID 0000-0002-6487-3121
Phil S BaranDepartment of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.ORCID 0000-0001-9193-9053

Funding

Scalable Synthesis and New Bond DisconnectionsR35GM118176 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI BARAN, PHIL S · 2016 to 2025
$11.5M
NIGMS NIH HHS R35 GM118176
6 · The paper itself

Abstract

An operationally simple, scalable, and chemoselective method for the direct phosphorylation of alcohols using a P(V)-approach based on the Ψ-reagent platform is disclosed. The method features a broad substrate scope of utility in both simple and complex settings and provides access to valuable phosphorylated alcohols that would be otherwise difficult to obtain.

Indexed as

AlcoholsCatalysisIndicators and ReagentsMolecular StructurePhosphorylationAlcoholsIndicators and Reagents

Identifiers

PMID34499517
PMCPMC8733960

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.