Evidence map›Paper›PMID 34499416›Full record

ArticleCancer medicine2021

Merestinib monotherapy or in combination for japanese patients with advanced and/or metastatic cancer: A phase 1 study.

Toshihiko Doi, Noboru Yamamoto, Yoichi Naito, Yasutoshi Kuboki, Takafumi Koyama, Yongzhe Piao, Naoto Tsujimoto, Hiroya Asou, Koichi Inoue, Shunsuke Kondo

Open access · goldAbstract readClinical Trial, Phase IMulticenter Study
In one paragraph

Article in Cancer medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Toshihiko DoiNational Cancer Center Hospital East, Chiba, Japan.
Noboru YamamotoDepartment of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan.
Yoichi NaitoNational Cancer Center Hospital East, Chiba, Japan.ORCID 0000-0002-8490-9064
Yasutoshi KubokiNational Cancer Center Hospital East, Chiba, Japan.
Takafumi KoyamaDepartment of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan.ORCID 0000-0001-5807-8458
Yongzhe PiaoEli Lilly Japan K.K, Kobe, Japan.
Naoto TsujimotoEli Lilly Japan K.K, Kobe, Japan.
Hiroya AsouEli Lilly Japan K.K, Kobe, Japan.
Koichi InoueEli Lilly Japan K.K, Kobe, Japan.
Shunsuke KondoDepartment of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan.ORCID 0000-0001-9565-117X
Eli Lilly (Japan) · JPNational Cancer Center Hospital East · JPTokyo National Hospital · JP

Funding

Eli Lilly and Company
6 · The paper itself

Abstract

This phase 1, multi-center, nonrandomized, open-label, dose-escalation study consisted of Part A wherein merestinib 80 or 120 mg (40-mg tablets) was administered orally QD during a 28-day cycle to patients diagnosed with solid tumors and Part B wherein merestinib 80 mg (40-mg tablets) was administered orally QD, and cisplatin 25 mg/m

Indexed as

AdultAgedAntineoplastic AgentsFemaleHumansIndazolesJapanMaleMiddle AgedNeoplasm MetastasisNeoplasmsNiacinamideAntineoplastic AgentsIndazolesmerestinibNiacinamidebiliary tract neoplasmscarcinomametastasisphosphotransferasestoxicity

Identifiers

PMID34499416
PMCPMC8495281
OpenAlexW3196852683

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.