Evidence map›Paper›PMID 34499412›Full record

ArticleChemistryOpen2021

Design, Synthesis and Biological Activity of C3 Hemisynthetic Triterpenic Esters as Novel Antitrypanosomal Hits.

Laura Schioppa, Claire Beaufay, Natacha Bonneau, Marianela Sanchez, Cynthia Girardi, Aurélie Leverrier, Sergio Ortiz, Jorge Palermo, Jacques H Poupaert, Joëlle Quetin-Leclercq

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemistryOpen, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Laura SchioppaPharmacognosy Research Group, Louvain Drug Research Institute (LDRI), UCLouvain, Avenue E. Mounier B1.72.03, Louvain, B-1200, Belgium.
Claire BeaufayPharmacognosy Research Group, Louvain Drug Research Institute (LDRI), UCLouvain, Avenue E. Mounier B1.72.03, Louvain, B-1200, Belgium.
Natacha BonneauPharmacognosy Research Group, Louvain Drug Research Institute (LDRI), UCLouvain, Avenue E. Mounier B1.72.03, Louvain, B-1200, Belgium.
Marianela SanchezDepartamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pab. 2, 1428, Buenos Aires, Argentina.
Cynthia GirardiPharmacognosy Research Group, Louvain Drug Research Institute (LDRI), UCLouvain, Avenue E. Mounier B1.72.03, Louvain, B-1200, Belgium.
Aurélie LeverrierDepartamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pab. 2, 1428, Buenos Aires, Argentina.
Sergio OrtizPharmacognosy Research Group, Louvain Drug Research Institute (LDRI), UCLouvain, Avenue E. Mounier B1.72.03, Louvain, B-1200, Belgium.
Jorge PalermoDepartamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pab. 2, 1428, Buenos Aires, Argentina.
Jacques H PoupaertMedicinal Chemistry Research Group, Louvain Drug Research Institute (LDRI), UCLouvain, Avenue E. Mounier B1.72.04, Louvain, B-1200, Belgium.
Joëlle Quetin-LeclercqPharmacognosy Research Group, Louvain Drug Research Institute (LDRI), UCLouvain, Avenue E. Mounier B1.72.03, Louvain, B-1200, Belgium.
UCLouvain · BESolvay (Belgium) · BEFundación Ciencias Exactas y Naturales · ARUniversity of Buenos Aires · AR

Funding

Fonds De La Recherche Scientifique - FNRS
6 · The paper itself

Abstract

Research for innovative drugs is crucial to contribute to parasitic infections control and eradication. Inspired by natural antiprotozoal triterpenes, a library of 12 hemisynthetic 3-O-arylalkyl esters was derived from ursolic and oleanolic acids through one-step synthesis. Compounds were tested on Trypanosoma, Leishmania and the WI38 cell line alongside with a set of triterpenic acids. Results showed that the triterpenic C3 esterification keeps the antitrypanosomal activity (IC

Indexed as

AnimalsDrug DesignDrug Evaluation, PreclinicalEstersFemaleLeishmania mexicanaMiceParasitic Sensitivity TestsTriterpenesTrypanocidal AgentsTrypanosoma brucei bruceiEstersTriterpenesTrypanocidal Agentsantitrypanosomal drugsbiological activityin vivo studiessynthesis designterpenoids

Identifiers

PMID34499412
PMCPMC8428374
OpenAlexW3198219949

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.