Evidence map›Paper›PMID 34499351›Full record

ReviewCA: a cancer journal for clinicians2021

Cervical cancer prevention and control in women living with human immunodeficiency virus.

Philip E Castle, Mark H Einstein, Vikrant V Sahasrabuddhe

Open access · diamondAbstract readReview
In one paragraph

Review in CA: a cancer journal for clinicians, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed, 6 pooled it
20.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

134 citing papers in PubMed, 6 syntheses or guidelines pooled it, 195 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Community-based health literacy focused intervention for cervical cancer control among Black women living with human immunodeficiency virus: A randomized pilot trial.Health expectations : an international journal of public participation in health care and health policy · 2023
    Trial
  10. Automated acquisition of explainable knowledge from unannotated colposcopic images for predicting the natural course of CIN2.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Article
  11. GATA1 knockdown enhances CD8Journal of molecular histology · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. SOX1/PAX1 Methylation for Triage of HPV-Positive Women in Cervical Cancer Screening: A Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

74 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Philip E CastleDivision of Cancer Prevention, National Cancer Institute, National Institutes of Health, Rockville, Maryland.ORCID 0000-0002-6408-5985
Mark H EinsteinDepartment of Obstetrics, Gynecology, and Reproductive Health, Rutgers New Jersey Medical School, Newark, New Jersey.
Vikrant V SahasrabuddheDivision of Cancer Prevention, National Cancer Institute, National Institutes of Health, Rockville, Maryland.ORCID 0000-0002-0551-7346
National Institutes of Health · USRutgers, The State University of New Jersey · US

Funding

Consortium for Advancing Management and Prevention of Cancer in People with HIVUM1CA121947 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Joseph A. Sparano · 2015 to 2026
$253.7M
Partnership for Prevention of HPV-Associated Cancers in People Living with HIV: Brazil, Mexico, and Puerto Rico - Supplemental ExtensionU54CA242639 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI ELLSWORTH, GRANT B., GIULIANO, ANNA R. · 2019 to 2025
$9.4M
Intramural NIH HHS Z99 CA999999NCI NIH HHS U54 CA242639NCI NIH HHS UM1 CA121947
6 · The paper itself

Abstract

Despite being highly preventable, cervical cancer is the fourth most common cancer and cause of cancer death in women globally. In low-income countries, cervical cancer is often the leading cause of cancer-related morbidity and mortality. Women living with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome are at a particularly high risk of cervical cancer because of an impaired immune response to human papillomavirus, the obligate cause of virtually all cervical cancers. Globally, approximately 1 in 20 cervical cancers is attributable to HIV; in sub-Saharan Africa, approximately 1 in 5 cervical cancers is due to HIV. Here, the authors provide a critical appraisal of the evidence to date on the impact of HIV disease on cervical cancer risk, describe key methodologic issues, and frame the key outstanding research questions, especially as they apply to ongoing global efforts for prevention and control of cervical cancer. Expanded efforts to integrate HIV care with cervical cancer prevention and control, and vice versa, could assist the global effort to eliminate cervical cancer as a public health problem.

Indexed as

Early Detection of CancerFemaleHIV InfectionsHumansImmunocompromised HostPapillomavirus InfectionsPapillomavirus VaccinesPrecancerous ConditionsPrimary PreventionSecondary PreventionUterine Cervical NeoplasmsPapillomavirus VaccinesAfricacervical cancercytologyhuman immunodeficiency virus (HIV)human papillomavirus (HPV)low-income and middle-income countries (LMICs)preventionscreeningvaccinationvisual inspection after acetic acid (VIA)

Identifiers

PMID34499351
PMCPMC10054840
OpenAlexW3197613404

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.