Evidence map›Paper›PMID 34499332›Full record

ArticleNeurotoxicity research2021

The Role of PKC in Regulating NMDARs in Aluminum-Induced Learning and Memory Impairment in Rats.

Chanting He, Jingjing Ji, Xiaoyan Zhao, Yang Lei, Huan Li, Yanxia Hao, Shuhui Zhang, Jingsi Zhang, Chengjuan Liu, Jisheng Nie and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Neurotoxicity research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Molecular Mechanisms of AMPA Receptor Trafficking in the Nervous System.International journal of molecular sciences · 2023
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Chanting HeDepartment of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Jingjing JiFenyang College, Shanxi Medical University, Fenyang, 032200, Shanxi, China.
Xiaoyan ZhaoDepartment of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Yang LeiDepartment of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Huan LiDepartment of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Yanxia HaoDepartment of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Shuhui ZhangDepartment of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Jingsi ZhangDepartment of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Chengjuan LiuDepartment of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
Jisheng NieDepartment of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China. niejisheng@sxmu.edu.cn.
Qiao NiuDepartment of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China. niuqiao55@163.com.ORCID http://orcid.org/0000-0003-0015-3341
Shanxi Medical University · CN

Funding

national natural science foundation of china 81430078national natural science foundation of china 81872599
6 · The paper itself

Abstract

Aluminum is a widespread environmental neurotoxicant that can induce Alzheimer's disease (AD)-like damage, such as neuronal injury and impairment of learning and memory. Several studies have shown that aluminum could reduce the synaptic plasticity, but its molecular mechanism remains unclear. In this study, rats were treated with aluminum maltol (Al(mal)

Indexed as

AluminumAnimalsBlotting, WesternDose-Response Relationship, DrugHippocampusLearningMaleMemoryMorris Water Maze TestOpen Field TestProtein Kinase CRatsRats, Sprague-DawleyReal-Time Polymerase Chain ReactionReceptors, N-Methyl-D-AspartateAluminumProtein Kinase CReceptors, N-Methyl-D-AspartateAluminumCaMKIILearning and memoryN-methyl-D-aspartate receptorProtein kinase C

Identifiers

PMID34499332
OpenAlexW3198617888

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.