ArticleMaxillofacial plastic and reconstructive surgery2021
Bone regeneration of demineralized dentin matrix with platelet-rich fibrin and recombinant human bone morphogenetic protein-2 on the bone defects in rabbit calvaria.
Article in Maxillofacial plastic and reconstructive surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Revolutionizing Bone Regeneration with Grinder-Based Dentin Biomaterial: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Histological examination of the effect of concentrated growth factor (CGF) on healing outcomes after maxillary sinus floor augmentation surgery.Journal of medicine and life · 2023Trial
- Tooth-derived graft for preservation and reconstruction of orofacial bones: A comprehensive review.Journal of advanced periodontology & implant dentistry · 2026Review
- Time-Course Evaluation of the In Vivo Resorption Process of Calcium Phosphates/Poly(lactide-International journal of molecular sciences · 2026Article
- Clinical and Histological Outcomes of Autologous Dentin Matrix in Post-Extraction Alveolar Healing: A Pilot Randomized Clinical Trial.Journal of clinical medicine · 2026Article
- Tooth Graft and Platelet-Rich Fibrin Mixture for Oral Bone Reconstruction and Preservation: A Scoping Review.Clinical and experimental dental research · 2025Article
- Undemineralized dentin matrix particles accelerate blood vessel formation in a critical-sized skull defect through activating the TGF-β/PI3K signaling pathway.American journal of translational research · 2025Article
- Maxillary Sinus Augmentation with Autogenous Tooth Grafting Material: A Systematic Review.Biomimetics (Basel, Switzerland) · 2024Review
- In Vivo Evaluation of Regenerative Osteogenic Potential Using a Human Demineralized Dentin Matrix for Dental Application.Dentistry journal · 2024Article
- Demineralized dentin matrix for bone regeneration in dentistry: A critical update.The Saudi dental journal · 2024Review
- Evaluation of osteogenic potential of demineralized dentin matrix hydrogel for bone formation.BMC oral health · 2023Article
- Standardization of Animal Models and Techniques for Platelet-Rich Fibrin Production: A Narrative Review and Guideline.Bioengineering (Basel, Switzerland) · 2023Review
- Long-Term Changes in Adipose Tissue in the Newly Formed Bone Induced by Recombinant Human BMP-2 In Vivo.Biomimetics (Basel, Switzerland) · 2023Article
- The optimal scaffold for silk sericin-based bone graft: collagen versus gelatin.Maxillofacial plastic and reconstructive surgery · 2023Article
- Analysis of the effects of concentrated growth factor and low-level laser therapy on the bone healing.Heliyon · 2023Article
- Demineralized Dentin Matrix for Dental and Alveolar Bone Tissues Regeneration: An Innovative Scope Review.Tissue engineering and regenerative medicine · 2022Review
- Bone Regeneration of a 3D-Printed Alloplastic and Particulate Xenogenic Graft with rhBMP-2.International journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study was to evaluate the bone formation ability of demineralized dentin matrix (DDM) combined with platelet-rich fibrinogen (PRF) and DDM combined with recombinant human bone morphogenetic protein-2 (rhBMP-2) to improve the osteoinductive ability of DDM.
methodsAfter four bone defects with a diameter of 8mm were created in the calvarium of each rabbit, DDM was grafted into the first defect (experimental groups 1), a combination of DDM and PRF was grafted into the second defect (experimental groups 2), and DDM with absorbed rhBMP-2 was grafted into the third defect (experimental groups 3). The fourth defect was used as the control group. Twelve healthy male rabbits (New Zealand, white rabbits) weighing around 3.0-4.0 kg were used. Among 12 rabbits, 3 rabbits were sacrificed immediately after surgery and at 2, 4, and 8 weeks after surgery, respectively. Histopathologic analysis and histomorphometric analysis were conducted to evaluate bone formation in each group.
resultsThe PRF/DDM group did not show a significantly higher degree of new bone formation in calvarial bone defects than the DDM group at 2, 4, and 8 weeks postoperatively in histopathological findings and histomorphometric results. On the other side, the rhBMP-2/DDM group showed higher degrees of new bone formation and calcification, and the lamellae of bone matrix, which are observed in mature bone tissue, were more distinctly visible in the rhBMP-2/DDM group. Moreover, the rhBMP-2/DDM group showed a significantly higher amount of new bone formation, compared to the DDM group at 4 and 8 weeks postoperatively (P<0.05) in histomorphometric results.
conclusionThe DDM has great potential as a carrier for the maintenance and sustained release of rhBMP-2, which has been recently receiving wide attention as a type of signaling molecules to promote bone formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.