SynthesisNeurosurgical review2022
The incidence of postoperative cerebrospinal fluid leakage after elective cranial surgery: a systematic review.
Synthesis in Neurosurgical review, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05717335 (Observational Pilot Study With TachoSil as a Ventricular Sealant), which is not on this map. Cited by 19 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Observational Pilot Study With TachoSil as a Ventricular Sealant
Who cites it
19 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Efficacy and safety of endoscopic compared with open surgical repair of cerebrospinal fluid fistulas: a systematic review and meta-analysis.Neurosurgical review · 2025Pooled it
- Regional and systemic complications following glioma resection: a systematic review and meta-analysis.Neurosurgical review · 2025Pooled it
- Trends in CSF Leakage Associated with Duraplasty in Infratentorial Procedures over the Last 20 Years: A Systematic Review.Critical reviews in biomedical engineering · 2023Pooled it
- Collagen-bound fibrin sealant (TachoSil®) for dural closure in cranial surgery: single-centre comparative cohort study and systematic review of the literature.Neurosurgical review · 2022Pooled it
- Comparing the Effects of Absorbable versus Nonabsorbable Nasal Packing on Postoperative Outcomes Following Endoscopic Ventral Skull Base Surgery.Journal of neurological surgery. Part B, Skull base · 2026Article
- Bioengineered Materials for Skull Base Reconstruction-Current Clinical Applications: Systematic Review and Meta-analysis.Journal of neurological surgery. Part B, Skull base · 2026Article
- Development and Preliminary Validation of a Risk Assessment Tool for Subdural Hematoma in Patients with Intracranial Hypotension.Neurocritical care · 2026Article
- Temporal dynamics of ICP, PRx, CPP, and CPPopt in relation to functional outcome in spontaneous cerebellar hemorrhage.Critical care (London, England) · 2026Article
- Nomogram for Predicting the Risk of Post-Craniotomy Intracranial Infection in Patients With Brain Tumors.Cancer medicine · 2026Article
- Reducing complications in duraplasty with autologous dural graft material: A meta-analysis.Journal of cerebrovascular and endovascular neurosurgery · 2025Article
- A novel technique to avoid cerebrospinal fluid leaks following middle fossa approaches: Identifying a new triangle in the middle fossa.Surgical neurology international · 2025Article
- Effectiveness and safety of Tachosil® as a ventricular sealant: an observational cohort study.Acta neurochirurgica · 2024Observational
- Preventing Post-incisional Dural Shrink in Craniotomy: Introducing the "Roll-up Technique".Neurologia medico-chirurgica · 2024Article
- Review
- Case Report: First use of dental bisphenol A-glycidyl methacrylate composite without UV light polymerization for repair of iatrogenic CSF leak following a frontal craniotomy plus tumor resection.Frontiers in surgery · 2024Article
- Article
- Cerebrospinal fluid leakage prevention using the anterior transpetrosal approach with versus without postoperative spinal drainage: an institutional cohort study.Neurosurgical review · 2023Article
- Article
- Comparison of microscopic transsphenoidal surgery and neuroendoscopic transsphenoidal surgery in pituitary adenoma resection and the risk factors of postoperative cerebrospinal fluid leakage.American journal of translational research · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebrospinal fluid (CSF) leakage is a major complication after elective neurosurgical procedures. The aim of this systematic literature review is to summarize the incidence rates of postoperative cerebrospinal fluid leakage for neurosurgical procedures, classified by surgical approach. The Pubmed, Cochrane, Embase, and Web of Science databases were searched for studies reporting the outcome of patients undergoing elective neurosurgical procedures. The number of patients, surgical approach, and indication for surgery were recorded for each study. Outcomes related to CSF leakage such as clinical manifestation and treatment were reported as well. One hundred and thirteen studies were included, reporting 94,695 cases. Overall, CSF leaks were present in 3.8% of cases. Skull base surgery had the highest rate of CSF leakage with 6.2%. CSF leakage occurred in 5.9% of anterior skull base procedures, 6.4% of middle fossa, and 5.2% of transpetrosal surgeries. 5.8% of reported infratentorial procedures were complicated by CSF leakage versus 2.9% of supratentorial surgeries. CSF leakage remains a common serious adverse event after cranial surgery. There exists a need for standardized procedures to reduce the incidence of postoperative CSF leakage, as this serious adverse event may lead to increased health care costs.
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Registered trials
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