Evidence map›Paper›PMID 34499234›Full record

ReviewCurrent allergy and asthma reports2021

Role of Environmental Air Pollution in Chronic Rhinosinusitis.

Evelyn M Leland, Zhenyu Zhang, Kathleen M Kelly, Murugappan Ramanathan

Open access · greenAbstract readReview
In one paragraph

Review in Current allergy and asthma reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Establishing the PMThe Journal of allergy and clinical immunology · 2026
    Article
  4. Inflammatory Shift in Chronic Rhinosinusitis Amidst Guangzhou's Urbanization (2000-2018).World journal of otorhinolaryngology - head and neck surgery · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Association Between Particulate Matter Exposure and Chronic Rhinosinusitis.Journal of rhinology : official journal of the Korean Rhinologic Society · 2023
    Review
  14. Review
  15. Review
  16. Solid Anorganic Particles and Chronic Rhinosinusitis: A Histopathology Study.International journal of environmental research and public health · 2022
    Article
  17. Article
  18. Does Particulate Matter Really Affect Sinusitis?Clinical and experimental otorhinolaryngology · 2021
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Evelyn M LelandDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, 601 N. Caroline St. JHOC 6263, Baltimore, MD, USA.
Zhenyu ZhangDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, 601 N. Caroline St. JHOC 6263, Baltimore, MD, USA.
Kathleen M KellyDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, 601 N. Caroline St. JHOC 6263, Baltimore, MD, USA.
Murugappan RamanathanDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, 601 N. Caroline St. JHOC 6263, Baltimore, MD, USA. mramana3@jhmi.edu.ORCID 0000-0002-7612-9586
Johns Hopkins University · US

Funding

The Role of Nrf2 in Stabilizing the Epithelial Barrier in Particulate Matter Induced RhinosinusitisR01AI143731 · NIAID · JOHNS HOPKINS UNIVERSITY · PI RAMANATHAN, MURUGAPPAN · 2019 to 2023
$2.2M
NIAID NIH HHS R01 AI143731
6 · The paper itself

Abstract

purpose of reviewChronic rhinosinusitis (CRS) is a highly prevalent disease with large social and financial burdens. The pathophysiology is multifactorial. Environmental pollutants have been suggested to play a role in the inflammatory component of the disease process. RECENT

findingsRecent work has focused on exposure to various pollutants, primarily particulate matter (PM). Exposure to environmental pollutants leads to upregulation of inflammatory markers and ciliary dysfunction at the cellular level. Mouse models suggest a role for epithelial barrier dysfunction contributing to inflammatory changes after pollutant exposure. Clinical studies support the role of pollutants contributing to disease severity in certain populations, but the role in CRS incidence or prevalence is less clear. Research is limited by the retrospective nature of most studies. This review focuses on recent advancements in our understanding of the impact of environmental pollutants in CRS, limitations of the available data, and potential opportunities for future studies.

Indexed as

Air PollutantsAir PollutionAnimalsEnvironmental ExposureHumansMiceParticulate MatterRetrospective StudiesAir PollutantsParticulate MatterAir pollutionChronic rhinosinusitisEnvironmental exposureEnvironmental pollutantsPollution

Identifiers

PMID34499234
PMCPMC8590820
OpenAlexW3198087242

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.