Evidence map›Paper›PMID 34499216›Full record

ArticleArchives of microbiology2021

Multidrug-resistant Raoultella ornithinolytica misidentified as Klebsiella oxytoca carrying blaOXA β-lactamases: antimicrobial profile and genomic characterization.

Iliana Alejandra Cortés-Ortíz, Edgar Mendieta-Condado, Noé Escobar-Escamilla, Julio César Juárez-Gómez, Fabiola Garcés-Ayala, Adnan Araíza Rodriguez, Juan Carlos Bravata-Alcántara, Víctor Hugo Gutiérrez-Muñoz, Juan Manuel Bello-López, José Ernesto Ramírez-González

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Iliana Alejandra Cortés-OrtízLaboratorio de Genética y Diagnóstico Molecular, Hospital Juárez de México. Secretaria de Salud, CDMX, México.
Edgar Mendieta-CondadoUnidad de Desarrollo Tecnológico e Investigación Molecular, Instituto de Diagnóstico y Referencia Epidemiológicos (InDRE) "Dr. Manuel Martínez Báez". Secretaria de Salud, Francisco de P. Miranda 177, Lomas de Plateros, Álvaro Obregón, 01480, CDMX, México. emendiet76@gmail.com.ORCID http://orcid.org/0000-0002-1041-0965
Noé Escobar-EscamillaUnidad de Desarrollo Tecnológico e Investigación Molecular, Instituto de Diagnóstico y Referencia Epidemiológicos (InDRE) "Dr. Manuel Martínez Báez". Secretaria de Salud, Francisco de P. Miranda 177, Lomas de Plateros, Álvaro Obregón, 01480, CDMX, México.ORCID http://orcid.org/0000-0001-8929-476X
Julio César Juárez-GómezLaboratorio de Bacteriología., Laboratorio Central. Hospital Juárez de México. Secretaria de Salud, CDMX, México.
Fabiola Garcés-AyalaUnidad de Desarrollo Tecnológico e Investigación Molecular, Instituto de Diagnóstico y Referencia Epidemiológicos (InDRE) "Dr. Manuel Martínez Báez". Secretaria de Salud, Francisco de P. Miranda 177, Lomas de Plateros, Álvaro Obregón, 01480, CDMX, México.
Adnan Araíza RodriguezUnidad de Desarrollo Tecnológico e Investigación Molecular, Instituto de Diagnóstico y Referencia Epidemiológicos (InDRE) "Dr. Manuel Martínez Báez". Secretaria de Salud, Francisco de P. Miranda 177, Lomas de Plateros, Álvaro Obregón, 01480, CDMX, México.
Juan Carlos Bravata-AlcántaraLaboratorio de Genética y Diagnóstico Molecular, Hospital Juárez de México. Secretaria de Salud, CDMX, México.
Víctor Hugo Gutiérrez-MuñozVigilancia Epidemiológica., Hospital Juárez de México. Secretaria de Salud, CDMX, México.
Juan Manuel Bello-LópezDivisión de Investigación., Hospital Juárez de México. Secretaria de Salud, CDMX, México.
José Ernesto Ramírez-GonzálezUnidad de Desarrollo Tecnológico e Investigación Molecular, Instituto de Diagnóstico y Referencia Epidemiológicos (InDRE) "Dr. Manuel Martínez Báez". Secretaria de Salud, Francisco de P. Miranda 177, Lomas de Plateros, Álvaro Obregón, 01480, CDMX, México.
Hospital Juárez de México · MXSecretaria de Salud · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Class D β-lactamases OXA-232 and OXA-48 hydrolyze penicillin, cephalosporins and carbapenems, limiting the pharmacological therapeutics in bacteraemia. OXA producer microorganisms are considered a great emergent threat, especially in nosocomial environments. To determine the resistance profile and genomic characterization of two isolates initially identified as potential carbapenemase-producer Klebsiella oxytoca in a third level hospital. Automated platform BD Phoenix-100 System was used to identify and to biochemically characterize both isolates. Furthermore, the resistance profile was determined through CLSI methods and the whole genome sequences were obtained using Next-Generation Sequencing. Resistance genes were analyzed, and the virtual fingerprinting was determined to corroborate the similarity with related bacteria. Both strains correspond to Raoultella ornithinolytica carrying OXA 232 and OXA-48 genes, confirming the class D β-lactamases assay results. Here, we present the genetic and phenotypic analysis of multidrug resistance R. ornithinolytica, representing the first report in Mexico.

Indexed as

beta-LactamasesKlebsiella oxytocaAnti-Bacterial AgentsBacterial ProteinsEnterobacteriaceaeGenomicsMicrobial Sensitivity TestsAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesAntimicrobial resistanceExtended spectrum carbapenemasesNosocomial infectionPlasmid mediated resistanceRaoultella ornithinolytica

Identifiers

PMID34499216
OpenAlexW3198423206

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.