Evidence map›Paper›PMID 34499087›Full record

ReviewAnesthesiology2022

Perioperative Pulmonary Atelectasis: Part I. Biology and Mechanisms.

Congli Zeng, David Lagier, Jae-Woo Lee, Marcos F Vidal Melo

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Anesthesiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 96 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06069414 completednot on this mapstarted 2023, after this paper: background citation

Atelectasis Evaluated With Lung Ultrasound After Inhalation or Intravenous Induction in Pediatric Anesthesia: a Prospective, Observational, Propensity Scored Matched Study

TypeobservationalSponsorVittore Buzzi Children's HospitalRan2023 to 2023Enrolled326ConditionsAtelectasis, Pediatric AnesthesiaArmsType of anesthesia induction
NCT06239831 recruitingnot on this map

Postoperative Respiratory and Activity Monitoring

TypeobservationalSponsorUniversity of Colorado, DenverRan2022 to 2026Enrolled30ConditionsHypoventilation, Hypoxemia, Postoperative Pulmonary ComplicationsArmsExSpiron and ActivPAL Monitors
3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Congli ZengDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
David LagierDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Jae-Woo Leethe Department of Anesthesia, University of California San Francisco, San Francisco, California.
Marcos F Vidal MeloDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Funding

1/2: An Anesthesia-Centered Bundle to Reduce Postoperative Pulmonary Complications: The PRIME-AIR StudyUH3HL140177 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI FERNANDEZ-BUSTAMANTE, ANA, VIDAL MELO, MARCOS F · 2020 to 2023
$6.6M
Regional Tidal Lung Strain and Neutrophilic Inflammation in Early Lung InjuryR01HL121228 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI VIDAL MELO, MARCOS F · 2014 to 2023
$6.2M
Human Mesenchymal Stem Cell Microvesicles for the Treatment of Acute Lung InjuryR01HL113022 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, JAE WOO · 2012 to 2020
$4.1M
Therapeutic Use of High Molecular Weight Hyaluronic Acid in Acute Lung Injury Following Severe Bacterial Pneumonia or SepsisR01HL148781 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ENKHBAATAR, PERENLEI, LEE, JAE WOO · 2020 to 2023
$3.2M
NHLBI NIH HHS R01 HL113022NHLBI NIH HHS R01 HL121228NHLBI NIH HHS R01 HL148781NHLBI NIH HHS UH3 HL140177
6 · The paper itself

Abstract

Pulmonary atelectasis is common in the perioperative period. Physiologically, it is produced when collapsing forces derived from positive pleural pressure and surface tension overcome expanding forces from alveolar pressure and parenchymal tethering. Atelectasis impairs blood oxygenation and reduces lung compliance. It is increasingly recognized that it can also induce local tissue biologic responses, such as inflammation, local immune dysfunction, and damage of the alveolar-capillary barrier, with potential loss of lung fluid clearance, increased lung protein permeability, and susceptibility to infection, factors that can initiate or exaggerate lung injury. Mechanical ventilation of a heterogeneously aerated lung (e.g., in the presence of atelectatic lung tissue) involves biomechanical processes that may precipitate further lung damage: concentration of mechanical forces, propagation of gas-liquid interfaces, and remote overdistension. Knowledge of such pathophysiologic mechanisms of atelectasis and their consequences in the healthy and diseased lung should guide optimal clinical management.

Indexed as

AnimalsDiaphragmHumansIntraoperative ComplicationsLungPerioperative CarePulmonary AtelectasisRespiration, Artificial

Identifiers

PMID34499087
PMCPMC9869183

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.